Breast malignant, males, children
Carcinoma subtypes
Acantholytic subtype of squamous cell carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 30 December 2016, last major update August 2012

Copyright: (c) 2001-2016,, Inc.

PubMed Search: acantholytic squamous cell carcinoma breast
Cite this page: Acantholytic subtype of squamous cell carcinoma. website. Accessed August 15th, 2018.
Definition / general
  • Acantholysis (lack of cell adhesion) is due to a desmosomal defect, possibly alteration in keratins (Cell Cycle 2008;7:2021)
  • May be very aggressive
  • Also called pseudoglandular or adenoid squamous cell carcinoma
Case reports
Gross images

Images hosted on other servers:

Cystic area with necrosis (upper), gray white solid area (below)

Microscopic (histologic) description
  • Pseudovascular or pseudoglandular appearance due to tumor cell discohesiveness
  • Lining is composed of squamous epithelium and spaces with necrotic debris and keratin
Microscopic (histologic) images

Images hosted on other servers:


Various images

Conjunctival tumor:

Pseudoglandular pattern
due to acantholysis of
neoplastic squamous cells

Head and neck:

Pseudolumina are present, but no true glands


Various images

Positive stains
Negative stains
Differential diagnosis