Table of ContentsDefinition / General | Terminology | Case Reports | Gross Images | Micro Description | Micro Images | Positive Stains | Negative Stains | Differential Diagnosis
Cite this page: Acantholytic subtype of squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsccacantholytic.html. Accessed January 23rd, 2017.
Definition / General
- Acantholysis (lack of cell adhesion) is due to a desmosomal defect, possibly alteration in keratins (Cell Cycle 2008;7:2021)
- May be very aggressive
- Also called pseudoglandular or adenoid squamous cell carcinoma
- Pseudovascular or pseudoglandular appearance due to tumor cell discohesiveness
- Lining is composed of squamous epithelium and spaces with necrotic debris and keratin