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Breast-malignant, males, children
Sebaceous carcinoma
Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.
Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)
Revised: 18 September 2009
Last major update: September 2009
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Very rare primary breast carcinoma resembling skin adnexal tumor with sebaceous differentiation, but no evidence of cutaneous derivation
Clinical
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● Associated with Muir-Torre syndrome (Cancer 2005;103:1018)
Case reports
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● 43 year old woman with tumor of skin of breast (J Med Case Reports 2008 Aug 15;2:276)
● 45 year old woman with extensive metastatic disease (Pathol Int 2000;50:63)
● 46 year old woman with Muir-Torre syndrome (AJR Am J Roentgenol 2000;174:541)
● 50 year old woman (Pathol Int 2009;59:188)
● 63 year old woman (Virchows Arch 2006;449:484)
● 83 year old woman with tumor of nipple (J Cutan Pathol 2008;35:608)
Microscopic description
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● Well defined solid sheets or lobules of atypical epithelial cells, including large pale or clear cells with coarsely vacuolated cytoplasm containing Oil red O staining lipid, and often scalloped nuclei
● Often focal squamous morules
Micro images
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Low power High power Focal calcification and necrosis
Multivacuolated cells with clear
cytoplasm and indented nuclei
Conjunctiva:
Sebaceous carcinoma
Skin:
Various images
Positive stains
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● Cytokeratin, including 35betaH11 (Pathol Res Pract 1993;189:888), EMA
● ER, PR, Oil Red O
● Some cells may express neuroendocrine markers
Negative stains
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● GCDFP-15, CEA, S100, vimentin
● Alpha smooth muscle actin, p63, androgen receptor (usually), mucins, HER2, CK15
Electron microscopy
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● Empty appearing non-membrane bound vacuoles
Differential diagnosis
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● Apocrine carcinoma
● Lipid rich carcinoma
End of Breast – Malignant, Males, Children > Sebaceous carcinoma
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