Invasive breast carcinoma of no special type and variants

Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2001-2019,, Inc.

PubMed search: sebaceous carcinoma breast

Monika Roychowdhury, M.D.
Page views in 2019: 2,460
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Cite this page: Roychowdhury M. Sebaceous. website. Accessed November 25th, 2020.
Definition / general
  • Very rare primary breast carcinoma resembling skin adnexal tumor with sebaceous differentiation, but no evidence of cutaneous derivation (see J Med Case Rep 2008;2:276 for cutaneous tumor of breast)
Clinical features
Case reports
Microscopic (histologic) description
  • Well defined solid sheets or lobules of atypical epithelial cells, including large, pale or clear cells with coarsely vacuolated cytoplasm, containing Oil red O staining lipid and often scalloped nuclei
  • Often focal squamous morules
Microscopic (histologic) images

Images hosted on other servers:

Focal calcification and necrosis

Contributed by Dr. Semir Vranic, University of Sarajevo (Bosnia)

Skin: various images

Positive stains
Electron microscopy description
  • Empty appearing, non membrane bound vacuoles
Differential diagnosis
  • Apocrine carcinoma: > 90% of tumor cells have cytologic or immunohistochemical features of apocrine cells
  • Lipid rich carcinoma: usually not coarsely vacuolated, often squamous morules, usually HER2+, ER-, PR-
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