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Breast-malignant, males, children

Sebaceous carcinoma

 

Author: Nat Pernick, M.D, PathologyOutlines.com, Inc.

Reviewer: Daniel Visscher, M.D., University of Michigan Hospitals, February 2009 (see Reviewers page)

Revised: 18 September 2009

Last major update: September 2009

Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.

 

Definition

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● Very rare primary breast carcinoma resembling skin adnexal tumor with sebaceous differentiation, but no evidence of cutaneous derivation

 

Clinical

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Associated with Muir-Torre syndrome (Cancer 2005;103:1018)

 

Case reports

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43 year old woman with tumor of skin of breast (J Med Case Reports 2008 Aug 15;2:276)

● 45 year old woman with extensive metastatic disease (Pathol Int 2000;50:63)

● 46 year old woman with Muir-Torre syndrome (AJR Am J Roentgenol 2000;174:541)

50 year old woman (Pathol Int 2009;59:188)

● 63 year old woman (Virchows Arch 2006;449:484)

● 83 year old woman with tumor of nipple (J Cutan Pathol 2008;35:608)

 

Microscopic description

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● Well defined solid sheets or lobules of atypical epithelial cells, including large pale or clear cells with coarsely vacuolated cytoplasm containing Oil red O staining lipid, and often scalloped nuclei

● Often focal squamous morules

 

Micro images

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Low power                           High power                                           Focal calcification and necrosis

 

 

Multivacuolated cells with clear

cytoplasm and indented nuclei

 

 

Conjunctiva:

Sebaceous carcinoma

 

 

Skin:

                     

Various images                                 

 

Positive stains

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● Cytokeratin, including 35betaH11 (Pathol Res Pract 1993;189:888), EMA

● ER, PR, Oil Red O

● Some cells may express neuroendocrine markers

 

Negative stains

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● GCDFP-15, CEA, S100, vimentin

● Alpha smooth muscle actin, p63, androgen receptor (usually), mucins, HER2, CK15

 

Electron microscopy

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● Empty appearing non-membrane bound vacuoles             

 

Differential diagnosis

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● Apocrine carcinoma

● Lipid rich carcinoma

 

End of Breast – Malignant, Males, Children > Sebaceous carcinoma

 

 

 

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