Breast malignant, males, children
Carcinoma subtypes
Sebaceous carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 30 December 2016, last major update August 2012

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PubMed search: sebaceous carcinoma breast

Cite this page: Sebaceous carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsebaceouscarcinoma.html. Accessed July 27th, 2017.
Definition / general
  • Very rare primary breast carcinoma resembling skin adnexal tumor with sebaceous differentiation, but no evidence of cutaneous derivation (see J Med Case Rep 2008;2:276 for cutaneous tumor of breast)
Clinical features
Case reports
Microscopic (histologic) description
  • Well defined solid sheets or lobules of atypical epithelial cells, including large, pale or clear cells with coarsely vacuolated cytoplasm, containing Oil red O staining lipid and often scalloped nuclei
  • Often focal squamous morules
Microscopic (histologic) images

Images hosted on other servers:

Focal calcification and necrosis

Contributed by Dr. Semir Vranic, University of Sarajevo (Bosnia)

Skin: various images

Positive stains
Electron microscopy description
  • Empty appearing, non membrane bound vacuoles
Differential diagnosis
  • Apocrine carcinoma: > 90% of tumor cells have cytologic or immunohistochemical features of apocrine cells
  • Lipid rich carcinoma: usually not coarsely vacuolated, often squamous morules, usually HER2+, ER-, PR-