Breast malignant, males, children
In situ carcinoma
Signet ring cell DCIS

Author: Dina Kandil, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Signet ring cell DCIS

Cite this page: Signet ring cell DCIS. website. Accessed October 22nd, 2016.
Definition / General
  • Not a distinct subtype of DCIS (Am J Clin Pathol 1980;73:31, Cancer 1985;55:2533)
  • Signet ring cells are usually associated with LCIS, but can be seen in DCIS as well; signet ring cells are very rare in benign ductal proliferation
Micro Description
  • Cells have eccentric nuclei that are indented at the nuclear border by a cytoplasmic vacuole with a central minute secretion droplet
Positive Stains
Differential Diagnosis
  • Clear cells of normal nipple-areola complex: varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)
  • Histiocytes: may appear in lymph nodes too; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)
  • Non-specific cytoplasmic halos: usually a fixation artifact, mucin negative