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Breast malignant, males, children

In situ carcinoma

Signet ring cell DCIS

Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 24 January 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Not a distinct subtype of DCIS (Am J Clin Pathol 1980;73:31, Cancer 1985;55:2533)
● Signet ring cells are usually associated with LCIS, but can be seen in DCIS as well; signet ring cells are very rare in benign ductal proliferation

Micro description

● Cells have eccentric nuclei that are indented at the nuclear border by a cytoplasmic vacuole with a central minute secretion droplet

Positive stains

● Mucicarmine, Alcian blue, PAS-diastase

Differential diagnosis

● Clear cells of normal nipple-areola complex: varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)
● Non-specific cytoplasmic halos: usually a fixation artifact, mucin negative
● Histiocytes: may appear in lymph nodes too; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)

End of Breast malignant, males, children > In situ carcinoma > Signet ring cell DCIS

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