Table of ContentsDefinition / General | Micro Description | Positive Stains | Differential Diagnosis
Cite this page: Signet ring cell DCIS. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsignetringcellDCIS.html. Accessed January 17th, 2017.
Definition / General
- Cells have eccentric nuclei that are indented at the nuclear border by a cytoplasmic vacuole with a central minute secretion droplet
- Clear cells of normal nipple-areola complex: varied morphology but no atypia; usually morphology consistent with pagetoid dyskeratosis, HMW CK+ (Histol Histopathol 2009;24:367)
- Histiocytes: may appear in lymph nodes too; mucin negative, CD68+ (Am J Clin Pathol 1989;92:509)
- Non-specific cytoplasmic halos: usually a fixation artifact, mucin negative