Breast malignant, males, children
Carcinoma subtypes
Small cell carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 2 January 2017, last major update August 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: small cell carcinoma breast
Cite this page: Small cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsmallcell.html. Accessed December 16th, 2017.
Definition / general
  • Similar morphologically to lung tumor
  • Diagnosis requires exclusion of other primaries or presence of DCIS
  • Also known as oat cell carcinomas, high grade neuroendocrine carcinoma, small cell undifferentiated carcinoma
  • May arise as variant of metaplastic carcinoma or from multipotential stem cells capable of divergent differentiation (Surg Today 2008;38:734)
  • Prognosis may not be as poor as previously thought (Am J Surg Pathol 2000;24:1231)
Epidemiology
  • Rare, usually ages 43 - 70 years
Case reports
Treatment
Gross description
  • Mean 3 cm, range 1 - 5 cm
Gross images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Microscopic (histologic) description
  • Typical small cell carcinoma features of scant cytoplasm, small (diameter of three lymphocytes) nuclei with finely granular, evenly distributed chromatin and absent or inconspicuous nucleoli
  • Frequent mitoses
  • Frequent crush artifact or nuclear streaming
  • Infiltrative borders, lymphatic tumor emboli and necrosis
  • Associated with invasive poorly differentiated carcinoma and lobular carcinoma
  • Associated with small cell in situ carcinoma and high grade DCIS
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick



Images hosted on other servers:

Chromogranin+

Neurone specific enolase+

H&E, p63, synaptophysin, TTF1


Classic features



Lung:

Classic features

Flow, H&E and stains (site unknown)

Cytology description
Cytology images

Images hosted on PathOut server:

FNAB, contributed by Dr. Mark R. Wick



Images hosted on other servers:

Clusters of monotonous neoplastic cells

Positive stains
Negative stains
Molecular / cytogenetics description
  • Small study shows similar genetic changes as both invasive ductal carcinoma and lung small cell carcinoma (Hum Pathol 2001;32:753)
Differential diagnosis