Breast malignant, males, children
In situ carcinoma
Reviewer: Dina Kandil, M.D. (see Reviewers page)
Revised: 26 January 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Ducts filled with uniform neoplastic cells without microlumina or papillary structures
● The lumen of the duct is filled by small to medium, uniform polygonal cells
● May produce a microacinar or rosette-like pattern
● Cells are larger than LCIS but smaller and more uniform than comedocarcinoma
● Cytoplasm can show a spectrum of changes including clear, granular and apocrine change
● Comedonecrosis is usually absent but small foci of necrosis may be present
● Usually low or intermediate grade (Anal Quant Cytol Histol 2001;23:418)
AFIP images: solid growth pattern with occlusion and distension of ducts by proliferation of cells with prominent nuclear pleomorphism (note: high grade features are not common in solid DCIS)
Solid pattern with central mucin
Intermediate grade based on cytologic features
● E-cadherin, ER, PR
● Lobular carcinoma in situ: sharp cell borders, dyshesive, E-cadherin negative (Semin Diagn Pathol 2004;21:25)
● Neuroendocrine carcinoma: chromatin has salt and pepper pattern, usually other neuroendocrine features
End of Breast malignant, males, children > In situ carcinoma > Solid cell DCIS
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