Breast malignant, males, children
In situ carcinoma
Solid DCIS

Author: Dina Kandil, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Solid DCIS

Cite this page: Solid DCIS. website. Accessed November 15th, 2018.
Definition / general
  • Ducts filled with uniform neoplastic cells without microlumina or papillary structures
Diagrams / tables

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Microscopic (histologic) description
  • The lumen of the duct is filled by small to medium, uniform polygonal cells
  • May produce a microacinar or rosette-like pattern
  • Cells are larger than LCIS but smaller and more uniform than comedocarcinoma
  • Cytoplasm can show a spectrum of changes including clear, granular and apocrine change
  • Comedonecrosis is usually absent but small foci of necrosis may be present
  • Usually low or intermediate grade (Anal Quant Cytol Histol 2001;23:418)
Microscopic (histologic) images

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AFIP images: solid growth pattern with occlusion and distension of ducts by proliferation of cells with prominent nuclear pleomorphism (note: high grade features are not common in solid DCIS)

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Various images

Intermediate grade based on cytologic features

Positive stains
Differential diagnosis