Solid DCIS

Breast malignant, males, children
In situ carcinoma
Solid DCIS

Author: Dina Kandil, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

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PubMed Search: Solid DCIS

Table of Contents

Cite this page: Solid DCIS. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsolidDCIS.html. Accessed July 14th, 2017.

Definition / general

Ducts filled with uniform neoplastic cells without microlumina or papillary structures

Diagrams / tables

Images hosted on other servers:

Drawing

Microscopic (histologic) description

The lumen of the duct is filled by small to medium, uniform polygonal cells
May produce a microacinar or rosette-like pattern
Cells are larger than LCIS but smaller and more uniform than comedocarcinoma
Cytoplasm can show a spectrum of changes including clear, granular and apocrine change
Comedonecrosis is usually absent but small foci of necrosis may be present
Usually low or intermediate grade (Anal Quant Cytol Histol 2001;23:418)

Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images: solid growth pattern with occlusion and distension of ducts by proliferation of cells with prominent nuclear pleomorphism (note: high grade features are not common in solid DCIS)

Images hosted on other servers:

Various images

Intermediate grade based on cytologic features

Positive stains

E-cadherin, ER, PR

Differential diagnosis

Lobular carcinoma in situ: sharp cell borders, dyshesive, E-cadherin negative (Semin Diagn Pathol 2004;21:25)
Neuroendocrine carcinoma: chromatin has salt and pepper pattern, usually other neuroendocrine features