Breast malignant, males, children
In situ carcinoma
Solid papillary DCIS

Author: Dina Kandil, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Solid papillary DCIS

Cite this page: Solid papillary DCIS. website. Accessed October 26th, 2016.
Definition / General
  • Also called neuroendocrine DCIS
  • Uncommon (2% of breast cancer)
  • Age 60+ years
Case Reports
Micro Description
  • Circumscribed, large cellular nodules separated by bands of dense fibrosis
  • Network of fibrovascular cores, but discrete papillae are not identified
  • Solid growth with cellular streaming and low grade, ovoid or spindled cells, resembling usual ductal hyperplasia
  • Cells may have endocrine features with granular eosinophilic cytoplasm and fine chromatin
  • May have pseudorosettes with palisading around small vascular spaces
  • Often mitotic figures
  • May have intracytoplasmic and extracellular mucin
Micro Images

Images hosted on PathOut server:

Inconspicuous fronds centrally (AFIP)

Images hosted on other servers:

Solid tumor with focal fibrovascular stroma

Solid variant with spindling

Tumor cells in cords
and festoons, with well
-defined fibrovascular
septa and vascular cores

Cytology Description
  • Malignant features include hypercellularity, highly discohesive clusters, numerous isolated cells and severe overcrowding
  • Benign features include small and bland nuclei, low nuclear-cytoplasmic ratio and inconspicuous nucleoli (Diagn Cytopathol 2007;35:417)
Positive Stains
Negative Stains
Differential Diagnosis
  • LCIS: no fibrovascular septa, no papillary features
  • Metastatic carcinoid: clinical history of primary, may not be papillary, usually ER negative
  • Solid variant of adenoid cystic carcinoma: biphasic with small inconspicuous intercalated ducts mixed with myoepithelium and small collagenous spherules
  • Usually ductal hyperplasia involving a papilloma: no atypia, mosaic staining pattern with CK5/6+