Breast malignant, males, children
In situ carcinoma
Spindle cell ductal carcinoma in situ

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Spindle cell ductal carcinoma in situ

Cite this page: Spindle cell ductal carcinoma in situ. website. Accessed October 24th, 2018.
Definition / general
  • Very rare (0.1% of breast carcinomas)
  • Mean age 59 years
Clinical features
  • Nipple discharge, breast lump or mammographic abnormality
Gross description
  • 3 to 41 mm
Microscopic (histologic) description
  • 10 - 80% of DCIS cells are spindled; patterns are fascicular, streaming or papillary
  • Solid growth pattern, lack of secondary spaces or peripheral fenestrations
  • Usually low to intermediate nuclear grade, with variable necrosis and microinvasion (Histopathology 2004;45:343)
Cytology description
  • Predominantly clusters and a small population of single cells in a necrotic background
  • Cells are mostly spindled, with minor population of epithelioid cells
  • Cells have high N/C ratio with hyperchromatic and pleomorphic nuclei and prominent nucleoli
  • Resembles metaplastic carcinoma (Acta Cytol 2005;49:323)
Positive stains
Negative stains
Differential diagnosis
  • Florid hyperplasia: HMW keratin+
  • Intraductal papilloma: no atypia
  • Metaplastic spindle cell tumors associated with fibrosclerotic lesions: Mod Pathol 2003;16:893
  • Myoepithelial hyperplasia: p63+, S100+, smooth muscle actin+
Additional references