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Breast malignant, males, children

In situ carcinoma

Squamous cell carcinoma in situ / Bowen’s disease


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 18 January 2012, last major update January 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Either intraepidermal tumor of nipple, or rarely a tumor of breast parenchyma (Am J Surg Pathol 2007;31:1414)

Case reports
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● 69 year old woman with coexisting basaloid carcinoma of nipple (Breast J 2009;15:409)
● Tumor of nipple (Hum Pathol 1994;25:1371)
● Tumor of nipple in young man with HIV (Clin Breast Cancer 2009;9:53)

Treatment and prognosis
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● Nipple tumor - wide local excision, possibly phototherapy (Breast 2005;14:65)
● Breast parenchyma tumor - standard treatment for DCIS (excision, possible radiotherapy)

Micro description / grading
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● Obvious squamous features with diffuse atypia
● May be extensive, but no dermal or myoepithelial invasion

Micro images
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Contributed by Dr. Amy Lynn, Toledo, Ohio - skin (not necessarily breast)

Positive stains
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● High molecular weight keratin

Negative stains
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● Mucin, melanin

Differential diagnosis
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Paget’s disease: CK7+, CAM5.2+ (J Cutan Pathol 2003;30:449)

End of Breast malignant, males, children > In situ carcinoma > Squamous cell carcinoma in situ / Bowen’s disease


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