Squamous cell carcinoma in situ / Bowen's disease

Breast malignant, males, children
In situ carcinoma
Squamous cell carcinoma in situ / Bowen’s disease

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 18 October 2016, last major update January 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Bowen’s disease [title]

Table of Contents

Cite this page: Squamous cell carcinoma in situ / Bowen's disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsquamouscellCIS.html. Accessed July 14th, 2017.

Definition / general

Either intraepidermal tumor of nipple, or rarely a tumor of breast parenchyma (Am J Surg Pathol 2007;31:1414)

Case reports

69 year old woman with coexisting basaloid carcinoma of nipple (Breast J 2009;15:409)
Tumor of nipple (Hum Pathol 1994;25:1371)
Tumor of nipple in young man with HIV (Clin Breast Cancer 2009;9:53)

Treatment

Nipple tumor: wide local excision, possibly phototherapy (Breast 2005;14:65)
Breast parenchyma tumor: standard treatment for DCIS (excision, possible radiotherapy)

Microscopic (histologic) description

Obvious squamous features with diffuse atypia
May be extensive, but no dermal or myoepithelial invasion

Microscopic (histologic) images

Images hosted on PathOut server:

Skin (not necessarily breast); courtesy of Dr. Amy Lynn

Positive stains

High molecular weight keratin

Negative stains

Mucin, melanin

Differential diagnosis

Paget’s disease: CK7+, CAM5.2+ (J Cutan Pathol 2003;30:449)