Breast malignant, males, children
Stromal sarcoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 December 2016, last major update August 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: stromal sarcoma breast
Cite this page: Stromal sarcoma. website. Accessed February 27th, 2017.
Definition / General
  • Also called periductal stromal sarcoma
  • Mean age 55 years, range 37 - 89 years
Prognostic Factors
  • May recur
Case Reports
  • Excision with negative margin
Clinical Images

Images hosted on PathOut server:

Mammogram, contributed by Dr. Mark R. Wick

Gross Description
  • Mean 3 cm, solid, gray-white, homogenous
Micro Description
  • Circumferential cuffs of predominantly uniform plump spindle cells with variable cellularity and atypia surrounding open tubules and ducts, but no phyllodes pattern
  • May have multiple nodules separated by adipose tissue
  • > 3 stromal mitotic figures per 10 HPF
  • Stromal infiltration into adjacent breast tissue
  • May have osseous metaplasia or resemble fibrosarcoma
  • Periductal stromal hyperplasia if no / minimal atypia and 0 - 2 stromal mitotic figures / 10 HPF
Micro Images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick

Images hosted on other servers:

H&E, periductal proliferation

H&E, regular epithelial structures

Atypical cells showing mitosis


Positive Stains
Negative Stains
  • ER, PR, myoepithelial markers
Electron Microscopy Description
  • Immature cells with abundant free ribosomes, profiles of rough ER, variable microfilaments
  • Often prominent cell nesting and a variety of cell junctions, including desmosomes (Cancer 1979;43:209)