Breast malignant, males, children - Suspicious for microinvasion

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Breast malignant, males, children

Breast cancer

Suspicious for microinvasion

Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 25 February 2012, last major update February 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Clinical description
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● In one study, 90% of core biopsies that were suspicious for invasion had definitive invasive disease at excision (Ann Surg Oncol 2007;14:704)

Micro description
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● Periductal or perilobular stroma contains either isolated individual neoplastic cells or rare clusters of cells thought to be neoplastic, but review of multiple levels fails to demonstrate continuity of cells/groups with adjacent in situ neoplasm or underlying residual epithelial structures

Micro images
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Various images (fig B, C, D)

Positive stains
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● Myoepithelial cells (favor noninvasive process) - p63 (sensitive and specific), smooth muscle actin (also stains myofibroblasts), calponin, smooth muscle myosin heavy chain
● Basement membrane - type IV collagen, laminin

Additional references
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● Mod Pathol 2002;15:95 (core biopsies), Am J Surg Pathol 2004;28:1076 (immunostains), Am J Surg Pathol 2003;27:82 (immunostains)

End of Breast malignant, males, children > Breast cancer > Suspicious for microinvasion

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