Suspicious for microinvasion

Breast malignant, males, children
Breast cancer
Suspicious for microinvasion

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 20 October 2016, last major update February 2012

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PubMed Search: Suspicious for microinvasion

Table of Contents

Clinical features | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Additional references

Cite this page: Suspicious for microinvasion. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignantsuspicious.html. Accessed July 14th, 2017.

Clinical features

In one study, 90% of core biopsies that were suspicious for invasion had definitive invasive disease at excision (Ann Surg Oncol 2007;14:704)

Microscopic (histologic) description

Periductal or perilobular stroma contains either isolated individual neoplastic cells or rare clusters of cells thought to be neoplastic, but review of multiple levels fails to demonstrate continuity of cells/groups with adjacent in situ neoplasm or underlying residual epithelial structures

Microscopic (histologic) images

Images hosted on other servers:

Various images (fig B, C, D)

Positive stains

Basement membrane: type IV collagen, laminin
Myoepithelial cells (favor noninvasive process): p63 (sensitive and specific), smooth muscle actin (also stains myofibroblasts), calponin, smooth muscle myosin heavy chain

Additional references

Mod Pathol 2002;15:95 (core biopsies), Am J Surg Pathol 2004;28:1076 (immunostains), Am J Surg Pathol 2003;27:82 (immunostains)