Breast malignant, males, children
Carcinoma subtypes
Tall cell like tumors

Topic Completed: 1 August 2012

Minor changes: 12 April 2019

Revised: 28 January 2019

Copyright: (c) 2001-2019,, Inc.

PubMed Search: tall cell variant of papillary thyroid carcinoma

Monika Roychowdhury, M.D.
Page views in 2019: 285
Page views in 2020 to date: 164
Cite this page: Roychowdhury M Tall cell like tumors. website. Accessed May 26th, 2020.
Definition / general
  • Not part of WHO breast classification
Clinical features
Microscopic (histologic) description
  • Solid or papillary nests of columnar / cuboidal cells with eosinophilic granular cytoplasm, round / oval nuclei with sharply defined nuclear membrane, nuclear grooves and eosinophilic pseudoinclusions
  • Also psammoma bodies
Cytology description
  • Abundant cellularity with isolated cells, sheets and papillary formations of epithelial cells with nuclear grooves (Int J Surg Pathol 2006;14:79)
Positive stains
Negative stains
Electron microscopy description
  • Cytoplasmic granules are mitochondria
Molecular / cytogenetics description
  • No BRAF mutations of thyroid carcinoma
Differential diagnosis
  • Metastatic tall cell variant of papillary thyroid carcinoma: clinical history of thyroid disease, thyroglobulin+, TTF1+ (Ann Pathol 1998;18:130)
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