!DOCTYPE html> Breast malignant, males, children - Tubular carcinoma


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General
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Clinical features
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Prognostic features
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Treatment
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Gross description
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Gross images
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Yellow-white sclerotic mass

Micro description
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Micro images
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Courtesy of Dr. Mark R. Wick

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H&E

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Well-defined glands

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Shares histologic features with radial scar

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Irregular neoplastic glands

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Multifocal and bilateral

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Angular glands with cytoplasmic snouts

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With cribriform DCIS

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Core biopsy

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Blue: malignant, Red: benign

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Tumor is CK5/6-; normal myoepithelial cells are CK5/6+

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p63 negative (fig e)



AFIP images:
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Angular glands with cytoplasmic snouts

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With collagenous and elastotic stroma and micropapillary DCIS

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With < 90% tubular component, arrows point to ductal-type

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Perineural invasion completely

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Axillary nodal metastasis

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Reticulin stains stromal fibers, fibers do no surround neoplastic glands

Positive stains
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Tubular breast cancer

Cytology description
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Positive stains
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Negative stains
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Molecular description
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Electron microscopy description
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Differential diagnosis
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End of Breast malignant, males, children > Carcinoma subtypes > Tubular carcinoma



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