Breast malignant, males, children
Carcinoma subtypes
Tubulolobular carcinoma

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 December 2016, last major update August 2012

Copyright: (c) 2001-2016,, Inc.

PubMed Search: tubulolobular carcinoma breast
Cite this page: Tubulolobular carcinoma. website. Accessed August 15th, 2018.
Definition / general
  • Not part of WHO breast classification
  • Median age 60 years, range 43 - 79 years
Prognostic factors
  • Intermediate prognostic features between lobular and ductal carcinoma
  • Best prognosis if unilateral and < 2 cm
  • 25% present with greater than stage I disease, compared to 0% with tubular and 60% with lobular carcinoma (Mod Pathol 2007;20:130)
  • Axillary nodal metastases in 13 - 43%
Case reports
Gross description
  • 0.5 to 2.5 cm, usually unilateral and 19 - 30% multifocal
Microscopic (histologic) description
  • Typical areas of invasive lobular carcinoma with cords of single file cells, which merge with small, round to angulated tubules with minute or undetectable lumina
  • Usually accompanied by DCIS, LCIS or both
  • Tumors are usually well differentiated with small, round nuclei and indistinct nucleoli
  • Stroma is densely collagenous with prominent elastosis
Microscopic (histologic) images

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AFIP images:

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Mixed tubular and lobular components

Figures a - d

Axillary nodal metastasis

E-cadherin (Fig 3a)

34betaE12 (negative in Fig 4a although usually positive)

Beta-catenin+ (Fig 6a)

p120 catenin+ (Fig 7a)

Small infiltrative glands

Tubulolobular breast immunophenotype

Contributed by Dr. Semir Vranic, University of Sarajevo (Bosnia)

Mixed tubular and lobular components

Cytology description
  • Single filing of cells and tubular structures
  • Tumor cells have intracytoplasmic vacuoles, low nuclear grade and low mitotic activity
  • Relatively clean background
  • Variable apocrine cells (Acta Cytol 1996;40:465)
Positive stains
Differential diagnosis