Breast
Other carcinoma subtypes, not WHO classified
Tubulolobular


Topic Completed: 1 August 2012

Minor changes: 21 June 2020

Copyright: 2001-2019, PathologyOutlines.com, Inc.

PubMed Search: tubulolobular carcinoma breast

Monika Roychowdhury, M.D.
Page views in 2019: 3,084
Page views in 2020 to date: 1,921
Cite this page: Roychowdhury M. Tubulolobular. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmalignanttubulolobular.html. Accessed August 7th, 2020.
Definition / general
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Median age 60 years, range 43 - 79 years
Prognostic factors
  • Intermediate prognostic features between lobular and ductal carcinoma
  • Best prognosis if unilateral and < 2 cm
  • 25% present with greater than stage I disease, compared to 0% with tubular and 60% with lobular carcinoma (Mod Pathol 2007;20:130)
  • Axillary nodal metastases in 13 - 43%
Case reports
Gross description
  • 0.5 to 2.5 cm, usually unilateral and 19 - 30% multifocal
Microscopic (histologic) description
  • Typical areas of invasive lobular carcinoma with cords of single file cells, which merge with small, round to angulated tubules with minute or undetectable lumina
  • Usually accompanied by DCIS, LCIS or both
  • Tumors are usually well differentiated with small, round nuclei and indistinct nucleoli
  • Stroma is densely collagenous with prominent elastosis
Microscopic (histologic) images

AFIP images

Arrow at tubules



Images hosted on other servers:

Small infiltrative glands

Tubulolobular breast immunophenotype


Contributed by Dr. Semir Vranic, University of Sarajevo (Bosnia)


Mixed tubular and lobular components

Cytology description
  • Single filing of cells and tubular structures
  • Tumor cells have intracytoplasmic vacuoles, low nuclear grade and low mitotic activity
  • Relatively clean background
  • Variable apocrine cells (Acta Cytol 1996;40:465)
Positive stains
Differential diagnosis
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