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Breast malignant, males, children

Breast cancer

WHO histological classification of tumors of the breast


Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 10 November 2012, last major update February 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

Background
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● Reflects views of Working Groups that convened in Lyon, France in January and March 2002
● Publication: Tavassoli: Tumours of the Breast and Female Genital Organs (WHO, 2003)
● Also listed below are ICD-O (morphology code) and behavior code: /0 for benign, /1 for borderline or uncertain, /2 for in situ and grade 3 intraepithelial neoplasia, /3 for malignant

Epithelial tumors
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● Invasive ductal carcinoma, not otherwise specified (NOS) - 8500/3
     ● Mixed type carcinoma
     ● Pleomorphic carcinoma - 8022/3
     ● Carcinoma with osteoclastic giant cells - 8035/3
     ● Carcinoma with choriocarcinomatous features
     ● Carcinoma with melanotic features
● Invasive lobular carcinoma - 8520/3
● Tubular carcinoma - 8211/3
● Invasive cribriform carcinoma - 8201/3
● Medullary carcinoma - 8510/3
● Mucinous carcinoma and other tumours with abundant mucin
     ● Mucinous carcinoma - 8480/3
     ● Cystadenocarcinoma and columnar cell mucinous carcinoma - 8480/3
     ● Signet ring cell carcinoma - 8490/3
● Neuroendocrine tumours
     ● Solid neuroendocrine carcinoma
     ● Atypical carcinoid tumour - 8249/3
     ● Small cell / oat cell carcinoma - 8041/3
     ● Large cell neuroendocrine carcinoma - 8013/3
● Invasive papillary carcinoma - 8503/3
● Invasive micropapillary carcinoma - 8507/3
● Apocrine carcinoma - 8401/3
● Metaplastic carcinomas - 8575/3
     ● Pure epithelial metaplastic carcinomas - 8575/3
     ● Squamous cell carcinoma - 8070/3
     ● Adenocarcinoma with spindle cell metaplasia - 8572/3
     ● Adenosquamous carcinoma - 8560/3
     ● Mucoepidermoid carcinoma - 8430/3
     ● Mixed epithelial/mesenchymal metaplastic carcinomas - 8575/3
● Lipid-rich carcinoma - 8314/3
● Secretory carcinoma - 8502/3
● Oncocytic carcinoma - 8290/3
● Adenoid cystic carcinoma - 8200/3
● Acinic cell carcinoma - 8550/3
● Glycogen-rich clear cell carcinoma - 8315/3
● Sebaceous carcinoma - 8410/3
● Inflammatory carcinoma - 8530/3
● Lobular neoplasia
     ● Lobular carcinoma in situ - 8520/2
● Intraductal proliferative lesions
     ● Usual ductal hyperplasia
     ● Flat epithelial atypia
     ● Atypical ductal hyperplasia
     ● Ductal carcinoma in situ - 8500/2
● Microinvasive carcinoma
● Intraductal papillary neoplasms
     ● Central papilloma - 8503/0
     ● Peripheral papilloma - 8503/0
     ● Atypical papilloma
     ● Intraductal papillary carcinoma - 8503/2
     ● Intracystic papillary carcinoma - 8504/2
● Benign epithelial proliferations
     ● Adenosis including variants: sclerosing adenosis, apocrine adenosis, blunt duct adenosis, microglandular adenosis, adenomyoepithelial adenosis
     ● Radial scar / complex sclerosing lesion
     ● Adenomas
          ● Tubular adenoma - 8211/0
          ● Lactating adenoma - 8204/0
          ● Apocrine adenoma - 8401/0
          ● Pleomorphic adenoma - 8940/0
          ● Ductal adenoma - 8503/0

Myoepithelial lesions
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● Myoepitheliosis
● Adenomyoepithelial adenosis
● Adenomyoepithelioma - 8983/0
● Malignant myoepithelioma - 8982/3

Mesenchymal Tumors
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● Hemangioma - 9120/0
● Angiomatosis
● Haemangiopericytoma - 9150/1
● Pseudoangiomatous stromal hyperplasia
● Myofibroblastoma - 8825/0
● Fibromatosis (aggressive) - 8821/1
● Inflammatory myofibroblastic tumour - 8825/1
● Lipoma - 8850/0
     ● Angiolipoma - 8861/0
● Granular cell tumour - 9580/0
● Neurofibroma - 9540/0
● Schwannoma - 9560/0
● Angiosarcoma - 9120/3
● Liposarcoma - 8850/3
● Rhabdomyosarcoma - 8900/3
● Osteosarcoma - 9180/3
● Leiomyoma - 8890/0
● Leiomyosarcoma - 8890/3

Fibroepithelial Tumors
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● Fibroadenoma - 9010/0
● Phyllodes tumour - 9020/1
     ● Benign - 9020/0
     ● Borderline - 9020/1
     ● Malignant - 9020/3
● Periductal stromal sarcoma, low grade - 9020/3
● Mammary hamartoma

Tumors of the nipple
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● Nipple adenoma - 8506/0
● Syringomatous adenoma - 8407/0
● Paget disease of the nipple - 8540/3

Malignant lymphoma
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● Diffuse large B cell lymphoma - 9680/3
● Burkitt lymphoma - 9687/3
● Extranodal marginal-zone B-cell lymphoma of MALT type - 9699/3
● Follicular lymphoma - 9690/3

Metastatic tumors - Tumors of the male breast
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● Gynaecomastia
● Carcinoma
     ● Invasive - 8500/3
     ● In situ - 8500/2

End of Breast malignant, males, children > Breast cancer > WHO histological classification of tumors of the breast


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