Breast nonmalignant
Benign tumors
Pleomorphic adenoma


Topic Completed: 1 April 2010

Minor changes: 2 April 2020

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PubMed Search Pleomorphic adenoma [title] breast


Hind Warzecha, M.D.
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Cite this page: Warzecha H. Pleomorphic adenoma . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastmixedtumor.html. Accessed May 27th, 2020.
Definition / general
  • Tumor with benign epithelial and stromal components similar to counterpart elsewhere but rare in breast
Terminology
  • Also called mixed tumor, chondroid syringoma (in skin)
Epidemiology
  • Rare in humans in breast ( < 100 cases reported, usually postmenopausal women)
Etiology
  • May derive from a single cell with divergent differentiation and not really be "mixed"
Radiology images

Contributed by Dr. Mark R. Wick

Mammogram

Case reports
Treatment
Gross description
  • Circumscribed, single or multiple yellow white firm nodules, 1 - 4 cm
  • Often subareolar
Microscopic (histologic) description
  • Similar to counterpart in salivary glands or skin (Am J Surg Pathol 1990;14:913)
  • Fibrous pseudocapsule surrounds benign glandular epithelial and myoepithelial cells in chondromyxoid or osseous stroma
  • Epithelial cells are arranged in tubules, islands, cords or sheets, are cuboidal or columnar with bland nuclear features and minimal mitotic figures
  • Myoepithelial cells are polygonal or stellate with clear to eosinophilic cytoplasm and small nuclei
Microscopic (histologic) images

AFIP images

Fibrosis, dilated ducts and chondroid metaplasia

 Contributed by Dr. Mark R. Wick

Parenchyma

Breast skin




Images hosted on other servers:

Fibrosis, dilated ducts and chondroid metaplasia

Cytology images

Contributed by Dr. Mark R. Wick

FNAB



Images hosted on other servers:

Hypercellular smears with cohesive fragments

Positive stains
Electron microscopy description
  • Intermediate filaments with dense bodies and intercellular junctions
Molecular / cytogenetics description
Differential diagnosis
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