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Breast-nonmalignant
Benign tumors / changes
Nodular mucinosis of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 5 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Very rare
Terminology
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● Also called nerve sheath myxoma of breast
Epidemiology
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● Usually young women
Sites
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Etiology
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Clinical features
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● Benign
Prognostic factors
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●
Case reports
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● 21 year old woman with breast mass (Archives 2005;129:e58)
● 30 year old woman with breast lump (Breast Cancer 2002;9:261)
● 72 year old woman with associated mucinous carcinoma (Am J Dermatopathol 2010;32:187)
● Occurring in supernumerary nipple (J Cutan Pathol 2009 Aug 19 [Epub ahead of print])
Treatment
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● Excision; does not recur
Clinical images
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●
Gross description (Macroscopy)
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● Variably circumscribed, subareolar myxoid mass
● Often multiple nodules of various sizes
Gross images
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Micro description (Histopathology)
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● Nodules of pink mucinous / myxoid material separated by vascularized fibrous septa
● Spindle cells with pale cytoplasm and indistinct borders and elongated, bland nuclei
● No mitotic figures, no invasion, no epithelial components within the nodules (may be at periphery)
Micro images
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Various images Skin Hales colloidal iron
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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● Spindle cells: vimentin, smooth muscle actin
● Mucin (acidic): Hale’s colloidal iron, Alcian blue
Negative stains
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● PAS (stains only neutral mucins), mucicarmine
Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Cutaneous follicular mucinosis: either present in hair follicles or associated with cutaneous T cell lymphoma
● Mucocele-like lesions: extension into breast stroma, PAS+ and mucicarmine+ mucin
● Myxoid fibroadenoma: mammary ducts, epithelial and myoepithelial cells
● Myxoid liposarcoma: S100+ lipoblasts
● Myxoid neurofibroma: neural cells, S100+
Additional references
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● Pathol Int 1998;48:542, Stanford University
End of Breast-nonmalignant > Benign tumors / changes > Nodular mucinosis
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