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Breast-nonmalignant

Benign tumors / changes

Nodular mucinosis of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 8 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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Very rare

 

Terminology

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Also called nerve sheath myxoma of breast

 

Epidemiology

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● Usually young women

 

Sites

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Etiology

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Clinical features

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Benign

 

Prognostic factors

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Case reports

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● 21 year old woman with breast mass (Archives 2005;129:e58)

● 30 year old woman with breast lump (Breast Cancer 2002;9:261)

72 year old woman with associated mucinous carcinoma (Am J Dermatopathol 2010;32:187)

● Occurring in supernumerary nipple (J Cutan Pathol 2009 Aug 19 [Epub ahead of print])

 

Treatment

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● Excision; does not recur

 

Clinical images

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Gross description (Macroscopy)

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● Variably circumscribed, subareolar myxoid mass

● Often multiple nodules of various sizes

 

Gross images

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Micro description (Histopathology)

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● Nodules of pink mucinous / myxoid material separated by vascularized fibrous septa

● Spindle cells with pale cytoplasm and indistinct borders and elongated, bland nuclei

● No mitotic figures, no invasion, no epithelial components within the nodules (may be at periphery)

 

Micro images

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Various images

 

Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Spindle cells: vimentin, smooth muscle actin

Mucin (acidic): Hale’s colloidal iron, Alcian blue

 

Negative stains

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● PAS (stains only neutral mucins), mucicarmine

 

Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Cutaneous follicular mucinosis: either present in hair follicles or associated with cutaneous T cell lymphoma

Mucocele-like lesions: extension into breast stroma, PAS+ and mucicarmine+ mucin

Myxoid fibroadenoma: mammary ducts, epithelial and myoepithelial cells

Myxoid liposarcoma: S100+ lipoblasts

Myxoid neurofibroma: neural cells, S100+

 

Additional references

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Pathol Int 1998;48:542, Stanford University

 

End of Breast-nonmalignant > Benign tumors / changes > Nodular mucinosis

 

 

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