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Breast-nonmalignant
General
Normal histology of breast

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 May 2014, last major update March 2010
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Major ducts:
Terminal duct lobular unit (TDLU):
Ductules (lobular ducts):
Intralobular connective tissue:
Interlobular connective tissue:
Nipple:
Areola:
Menstrual cycle related changes:
Clear cell change:
Pregnancy / lactation:
Post-menopausal:
Males:

Micro images
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Subgross


Normal lobules


Two layers


Terminal ductal lobular unit


AFIP Fig 9-10: clear cell change

Clear cell change, by Dr. Semir Vranic, Univ of Sarajevo (Bosnia)

Myoepithelial hyperplasia with clear, round
myoepithelial cells displacing glandular epithelial cells

AFIP Fig 333: myoid metaplasia derived from myoepithelial
cells (HHF+); squamous metaplasia arising in duct


Menstrual cycle changes


Aging related changes


Post-treatment: normal acini


Epithelial cells have ER+ nuclei

Epithelial cells have PR+ nuclei


E-cadherin


Myoepithelial stains:

Smooth muscle actin

Calponin


FOSB protein

p63+


CD10, smooth muscle actin and S100

Type IV collagenase (upper left)


Nipple:

With pilosebaceous units

Nipple and lactiferous duct


Lactiferous ducts


Cytology images
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Normal breast

Positive stains
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Basement membrane:
Epithelium / luminal cells:
Myoepithelial cells:
Toker cells:

Negative stains
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Myoepithelial cells:
Toker cells:

Electron microscopy images
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Acini

Glandular and myoepithelial cells

Molecular description
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Videos
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Normal breast

Differential diagnosis
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End of Breast-nonmalignant > General > Normal histology of breast


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