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General
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Terminology
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Epidemiology
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Etiology
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Clinical features
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Case reports
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Treatment
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Clinical images
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Mammogram, courtesy of Dr. Mark R. Wick

Gross description
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Gross images
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Intracystic, courtesy of Dr. Mark R. Wick

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Polypoid intraductal mass

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Hemorrhagic cyst with tan tumor

Micro description
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Micro images
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Arising in a small duct

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Fibrocystic changes

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Palpable subareolar mass

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Intricate branching fronds

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Duct markedly dilated

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Ducts dilated or cystic

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Irregular glandular spaces

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Multilayering ductal cells not prominent

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Ductal, myoepithelial & fibroblast cells

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Two-cell pattern

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Multiple nodules and stromal fibrosis

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Epithelial and myoepithelial cells

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Stromal fibrosis resembles invasion

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Central papilloma

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Papilloma with florid ductal hyperplasia

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Encysted papilloma with hyperplasia

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Peripheral papilloma

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Within lymph node

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Apocrine intraductal papilloma with large nuclei and prominent nucleoli

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Solid type

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Fusion of adjacent papillae, gland-like spaces

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Resembles sclerosing adenosis

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Infarcted papilloma

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With fibroblasts

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Small ducts surrounded by hyalinized fibrous tissue

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Squamous metaplasia

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With spindle cells

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Vessels but not spindle cells are actin+

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Atypia/malignancy

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Papilloma with atypia

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Papilloma with separate focus of ADH

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Papilloma with severe atypia

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With micropapillary DCIS

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With LCIS spreading in a pagetoid manner beneath ductal epithelium (plaque-like pattern)

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Various images

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p63

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Smooth muscle actin

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CD10 and smooth muscle actin

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In a dilated duct, H&E

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Within ectatic duct, H&E

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Inner layer of columnar cells columnar cells

Videos
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Cytology description
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Cytology images
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Leishman-Giemsa

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FNA

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Polygonal cells

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Columnar and polygonal cells

Positive stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Breast - nonmalignant > Benign tumors / changes > Papilloma of breast



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