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Breast-nonmalignant

Benign tumors / changes

Phyllodes Tumor - Borderline

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 8 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Has features intermediate between benign and malignant phyllodes tumors

 

Terminology

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● May be considered low grade malignant tumors

 

Epidemiology

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Sites

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Etiology

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Clinical features

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● 15-30% of phyllodes tumors (Asian J Surg 2009;32:224)

● Tend to recur, 9% may metastasize

 

Prognostic factors

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Case reports

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Treatment

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● Wide local excision

 

Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Moderate cellularity (between benign and malignant), 1-5 mitotic figures/10 HPF, partially or entirely infiltrative border

 

Micro images

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Borderline tumor

 

 

  

H&E and p53 staining

 

 

Ki-67

Fig A: benign tumor with minimal nuclear staining

Fig B: low grade malignant tumor with increased Ki-67

Fig C: high grade malignant tumor with frequent staining

 

Drawings

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Virtual Slides

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Virtual slide


Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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● Similar methylation profile (Virchows Arch 2009;455:469) and cytogenetics (Breast Cancer Res Treat 2008;112:411) as malignant phyllodes tumors

 

Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Phyllodes tumor - Borderline

 

 

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