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Definition
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Terminology
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Epidemiology
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Gross images
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Tumors with hemorrhage and necrosis

Micro description
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Micro images
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Hypercellular tumor with stromal overgrowth, atypia and mitotic figures

Multinucleated giant cells

Squamous metaplasia and keratin cysts

Osteochondroid metaplasia

Sarcomatous stroma


Pleomorphic nuclei

Infiltration into adipose tissue

Mitotic figures and abnormal mitotic figure

Multinucleated giant cells


Chondrosarcoma component

Fibrosarcomatous stroma


Liposarcoma component

MFH component

Osteosarcoma component


Rhabdomyosarcoma component

Sarcoma NOS component


Contributed by: Dr. Semir Vranic


Metastasis to thyroid Hurthle cell tumor

Ki-67
Fig A: benign tumor with minimal nuclear staining
Fig B: low grade malignant tumor with increased Ki-67
Fig C: high grade malignant tumor with frequent staining


p53+

p53

c-kit+ stromal cells and stromal giant cells



Cytology description
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Positive stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Breast - nonmalignant > Benign tumors / changes > Phyllodes Tumor - malignant



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