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Breast-nonmalignant
Inflammatory / infectious
Plasma cell mastitis
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 28 September 2012, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Considered a variant of periductal mastitis / duct ectasia with prominent plasma cell component
Terminology
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● Very few recent articles in English medical literature using this terminology
Epidemiology
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Sites
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Etiology
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● Plasma cell infiltrate may be due to retained milk secretions
● Associated with pregnancy, occurs a mean 4 years after cessation of lactation
Clinical features
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● Firm mass, 2-3 cm, with nipple discharge and retraction
● Often axillary adenopathy
● Resembles carcinoma clinically
Prognostic factors
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Case reports
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● 35 year old woman with breast abscess (Postgrad Med J 1958;34:654)
● 37 year old woman with bilateral involvement (Br Med J 1949;1:94)
Treatment
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● Excision to avoid ulceration and fistulas which may develop after partial removal
Clinical images
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Gross description (Macroscopy)
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● Dilated ducts with creamy secretion
Gross images
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Micro description (Histopathology)
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● Hyperplasia of ductal epithelium with markedly diffuse plasma cell infiltrate of ducts and lobules
● Often granulomatous reaction
Micro images
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Infiltrate of plasma cells, macrophages, lymphocytes
Virtual Slides
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Videos
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Cytology description
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● Prominent plasma cells and histiocytes
● Also hyperplastic epithelial cells
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● (link to topic)
Additional references
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End of Breast-nonmalignant > Inflammatory / infectious > Plasma cell mastitis
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