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Breast-nonmalignant

Inflammatory / infectious

Plasma cell mastitis

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 28 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Considered a variant of periductal mastitis / duct ectasia with prominent plasma cell component

 

Terminology

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● Very few recent articles in English medical literature using this terminology

 

Epidemiology

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Sites

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Etiology

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● Plasma cell infiltrate may be due to retained milk secretions

● Associated with pregnancy, occurs a mean 4 years after cessation of lactation

 

Clinical features

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● Firm mass, 2-3 cm, with nipple discharge and retraction

● Often axillary adenopathy

● Resembles carcinoma clinically

 

Prognostic factors

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Case reports

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● 35 year old woman with breast abscess (Postgrad Med J 1958;34:654)

● 37 year old woman with bilateral involvement (Br Med J 1949;1:94)

 

Treatment

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● Excision to avoid ulceration and fistulas which may develop after partial removal

 

Clinical images

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Gross description (Macroscopy)

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● Dilated ducts with creamy secretion

 

Gross images

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Micro description (Histopathology)

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● Hyperplasia of ductal epithelium with markedly diffuse plasma cell infiltrate of ducts and lobules

● Often granulomatous reaction

 

Micro images

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Infiltrate of plasma cells, macrophages, lymphocytes

 

Virtual Slides

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Videos

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Cytology description

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● Prominent plasma cells and histiocytes

● Also hyperplastic epithelial cells

 

Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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● (link to topic)

 

Additional references

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End of Breast-nonmalignant > Inflammatory / infectious > Plasma cell mastitis

 

 

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