Breast - nonmalignant
Fibrocystic disease
Pseudolactational (pregnancy-like) hyperplasia of breast

Author: Hind Nassar, M.D. (see Authors page)

Revised: 1 August 2017, last major update June 2010

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pregnancy-like hyperplasia

Cite this page: Pseudolactational (pregnancy-like) hyperplasia of breast. website. Accessed December 15th, 2018.
Definition / general
  • Pregnancy-like changes in a nonpregnant, nonlactating patient
  • Present in 2 - 3% of breast biopsies
  • Identified in needle localization and core biopsies due to calcifications or presence of a mass
  • Women, mean age 44 years, range 38 - 52 years
  • Not lactating, not pregnant (by definition)
Clinical features
Gross description
  • No gross lesion
Microscopic (histologic) description
  • Glands and terminal ducts with little or no secretion
  • Glandular cells are swollen with abundant pale or clear, finely granular or vacuolated cytoplasm
  • Luminal cytoplasmic borders of glandular cells are frayed with small cytoplasmic blebs extending into lumen that may contain nuclei
  • Small, uniform, round and darkly stained nuclei
Microscopic (histologic) images

Images hosted on PathOut server:

Expanded acinar glands

Cells have abundant pale cytoplasm but no secretion

Micropapillary pattern
of columnar cells with
luminal cytoplasmic buds

Images hosted on other servers:

Cells have finely vacuolated cytoplasm

Differential diagnosis