Breast nonmalignant
Nonneoplastic changes
Pseudolactational (pregnancy-like) hyperplasia

Topic Completed: 1 June 2010

Minor changes: 4 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Pregnancy-like hyperplasia

Hind Warzecha, M.D.
Page views in 2019: 1,854
Page views in 2020 to date: 836
Cite this page: Warzecha H. Pseudolactational (pregnancy-like) hyperplasia of breast. website. Accessed May 31st, 2020.
Definition / general
  • Pregnancy-like changes in a nonpregnant, nonlactating patient
  • Present in 2 - 3% of breast biopsies
  • Identified in needle localization and core biopsies due to calcifications or presence of a mass
  • Women, mean age 44 years, range 38 - 52 years
  • Not lactating, not pregnant (by definition)
Clinical features
Gross description
  • No gross lesion
Microscopic (histologic) description
  • Glands and terminal ducts with little or no secretion
  • Glandular cells are swollen with abundant pale or clear, finely granular or vacuolated cytoplasm
  • Luminal cytoplasmic borders of glandular cells are frayed with small cytoplasmic blebs extending into lumen that may contain nuclei
  • Small, uniform, round and darkly stained nuclei
Microscopic (histologic) images

AFIP images

Expanded acinar glands

Cells have abundant pale cytoplasm but no secretion


Micropapillary pattern
of columnar cells with
luminal cytoplasmic buds

Images hosted on other servers:

Cells have finely vacuolated cytoplasm

Differential diagnosis
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