Breast nonmalignant
General
Pubertal (virginal) macromastia


Topic Completed: 1 August 2014

Revised: 9 August 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Pubertal macromastia

Belinda Lategan, M.D.
Page views in 2018: 2,081
Page views in 2019 to date: 4,458
Cite this page: Lategan B. Pubertal (virginal) macromastia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastpubertalmacromastia.html. Accessed December 14th, 2019.
Definition / general
Terminology
  • Alternate terms:
    • Adolescent / juvenile macromastia / gigantomastia
  • Other forms of gigantomastia not specific to adolescence
    • Gravid macromastia
    • Penicillamine induced
Etiology
  • Unclear
  • Genetic
    • Mammary digital nail syndrome - rare
      • Anonychia onychodystrophy with hypoplasia or absence of distal phalanges in males and females (Eur J Hum Genet 2010;18:662)
      • Juvenile hypertrophy of the breast in affected females
  • Not associated with increased estrogen receptor protein expression in stroma
Clinical features
  • Sudden diffuse enlargement over 1 - 2 years during adolescence (average 6 months)
  • No subsequent involution
Treatment
Clinical images

Images hosted on other servers:

Adolescent macromastia

Virginal (juvenile) breast hypertrophy

Unilateral enlargement

Autoimmune related cases

Microscopic (histologic) description
  • Diagnosed based on clinical history and morphology
  • Resembles gynecomastia
    • Greatly increased stromal collagen and fat
    • Lobules may be reduced or poorly developed
    • Duct epithelial hyperplasia less common
    • Pseudoangiomatous stromal hyperplasia
Microscopic (histologic) images

AFIP images

15 year old girl



Images hosted on other servers:

Dense fibrosis with severe lobular atrophy

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