Breast - nonmalignant
Inflammatory / infectious
IgG4 related sclerosing mastitis

Author: Hind Nassar, M.D. (see Authors page)

Revised: 24 April 2018, last major update April 2010

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Sclerosing mastitis

Cite this page: IgG4 related sclerosing mastitis. website. Accessed July 23rd, 2018.
Definition / general
  • Newly described member of IgG4 related sclerosing diseases
  • In study of 4 women, mean age 47 years
  • IgG4 related sclerosing disease is a recently described syndrome of mass forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, with high serum IgG4 titers, increased IgG4 plasma cells, good clinical outcome
  • Also causes mastitis (Am J Surg Pathol 2009;33:1058)
Clinical features
  • Painless breast masses
  • No recurrence in small study
Microscopic (histologic) description
  • Loss of lobules due to dense lymphoplasmacytic infiltrates and prominent stromal sclerosis
  • Variable phlebitis
Positive stains
  • Numerous IgG4 plasma cells