Breast nonmalignant
IgG4 related sclerosing mastitis

Topic Completed: 1 April 2010

Minor changes: 3 September 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Sclerosing mastitis

Hind Warzecha, M.D.
Page views in 2019: 874
Page views in 2020 to date: 326
Cite this page: Nassar H. IgG4 related sclerosing mastitis. website. Accessed May 31st, 2020.
Definition / general
  • Newly described member of IgG4 related sclerosing diseases
  • In study of 4 women, mean age 47 years
  • IgG4 related sclerosing disease is a recently described syndrome of mass forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, with high serum IgG4 titers, increased IgG4 plasma cells, good clinical outcome
  • Also causes mastitis (Am J Surg Pathol 2009;33:1058)
Clinical features
  • Painless breast masses
  • No recurrence in small study
Microscopic (histologic) description
  • Loss of lobules due to dense lymphoplasmacytic infiltrates and prominent stromal sclerosis
  • Variable phlebitis
Positive stains
  • Numerous IgG4 plasma cells
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