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Breast-nonmalignant

Inflammatory / infectious

Sclerosing mastitis, IgG4 related

 

Reviewer:

Revised: 30 September 2012, last major update April 2010

Copyright: (c) 2010, PathologyOutlines.com, Inc.

 

Definition

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● Newly described member of IgG4 related sclerosing diseases

 

Terminology

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Epidemiology

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● In study of 4 women, mean age 47 years

 

Etiology

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● IgG4-related sclerosing disease is a recently described syndrome of mass forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, with high serum IgG4 titers, increased IgG4 plasma cells, good clinical outcome

● Also causes mastitis (Am J Surg Pathol 2009;33:1058)

 

Clinical features

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● Painless breast masses

 

Prognostic factors

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Case reports

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Treatment

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● No recurrence in small study

 

Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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Micro images

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● Loss of lobules due to dense lymphoplasmacytic infiltrates and prominent stromal sclerosis

● Variable phlebitis

 

Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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● Numerous IgG4 plasma cells

 

Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Inflammatory / infectious > Sclerosing mastitis

 

 

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