Breast - nonmalignant
Inflammatory / infectious
Silicone breast implants

Author: Hind Nassar, M.D. (see Authors page)

Revised: 27 July 2017, last major update April 2010

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Silicone breast implants [title]

Cite this page: Silicone breast implants. website. Accessed July 23rd, 2018.
Definition / general
  • Important to document gross and histologic findings associated with implant related specimens
Clinical features
Case reports
Microscopic (histologic) description
  • Chronic inflammatory response (plasma cells, B and T cells and foamy macrophages) with fibrotic capsule around the implant causing contracture of prosthesis (Aesthetic Plast Surg 2010;34:481)
  • Lining cells may resemble synovium (synovial metaplasia, Mod Pathol 1994;7:310)
  • Gel may seep through intact implant shells
  • May have foreign body reaction with sinus tracts
  • Numerous cystic spaces and vacuoles may exist where silicone dissolves during processing
Microscopic (histologic) images

Images hosted on PathOut server:

Refractile silicone and giant cell reaction (arrow at doubly refractile silicone)

Silicone globules,
giant cell
reaction, fibrosis

Polyurethane implant -
polyurethane (arrow)
and silicone
(round globules)

Images hosted on other servers:

Silicone globules, giant cell inflammatory reaction, fibrosis

Capsular synovial metaplasia

Silicone mastitis

Foreign body reaction to silicone