Breast nonmalignant
Silicone breast implants

Topic Completed: 1 April 2010

Revised: 23 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Silicone breast implants [title]

Hind Warzecha, M.D.
Page views in 2018: 4,135
Page views in 2019 to date: 3,510
Cite this page: Warzecha H. Silicone breast implants. website. Accessed August 25th, 2019.
Definition / general
  • Important to document gross and histologic findings associated with implant related specimens
Clinical features
Case reports
Microscopic (histologic) description
  • Chronic inflammatory response (plasma cells, B and T cells and foamy macrophages) with fibrotic capsule around the implant causing contracture of prosthesis (Aesthetic Plast Surg 2010;34:481)
  • Lining cells may resemble synovium (synovial metaplasia, Mod Pathol 1994;7:310)
  • Gel may seep through intact implant shells
  • May have foreign body reaction with sinus tracts
  • Numerous cystic spaces and vacuoles may exist where silicone dissolves during processing
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Giant cell reaction

AFIP images

Refractile silicone and giant cell reaction (arrow at doubly refractile silicone)

Silicone globules,
giant cell
reaction, fibrosis

Polyurethane implant -
polyurethane (arrow)
and silicone
(round globules)

Images hosted on other servers:

Silicone globules, giant cell inflammatory reaction, fibrosis

Capsular synovial metaplasia

Silicone mastitis

Foreign body reaction to silicone

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