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Breast-nonmalignant

Inflammatory / infectious

Silicone breast implants - axilla

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 30 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Due to silicone prosthesis or migration of injected silicone

● Either an incidental finding or causes painful / enlarged lymph node

 

Terminology

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Epidemiology

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Sites

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Etiology

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● Silicone in intact capsule may migrate to lymph nodes (Arch Pathol Lab Med 1981;105:371), possibly via macrophages

 

Clinical features

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Prognostic factors

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Case reports

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● Leaky implant associated with Kikuchi-Fujimoto disease (Arch Pathol Lab Med 1996;120:380)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Foamy macrophages and refractile droplets of clear material (Am J Surg Pathol 2005;29:506)

● Also coarse vacuoles, fine vacuoles, and multinucleated giant cells (Am J Surg Pathol 1988;12:484)

● Variable polygonal fragments of polyurethane

 

Micro images

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Figure 4                                                Figure 5

Vacuolated histiocytes expand                      Multinucleated giant cells contain

subcapsular sinus                                             refractile material

 

 

  

Round silicone vacuoles of various sizes

 

Other images: #1#2 

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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● Birefringent material with foreign body giant cells in lymphoid background (Acta Cytol 1999;43:1163)

 

Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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● Sinus histiocytosis with massive lymphadenopathy

 

Additional references

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End of Breast-nonmalignant > Inflammatory / infectious > Silicone breast implants-axilla

 

 

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