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Breast-nonmalignant
Inflammatory / infectious
Silicone breast implants - axilla
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 10 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Due to silicone prosthesis or migration of injected silicone
● Either an incidental finding or causes painful / enlarged lymph node
Terminology
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Epidemiology
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Sites
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Etiology
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● Silicone in intact capsule may migrate to lymph nodes (Arch Pathol Lab Med 1981;105:371), possibly via macrophages
Clinical features
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Prognostic factors
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Case reports
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● Leaky implant associated with Kikuchi-Fujimoto disease (Arch Pathol Lab Med 1996;120:380)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Foamy macrophages and refractile droplets of clear material (Am J Surg Pathol 2005;29:506)
● Also coarse vacuoles, fine vacuoles, and multinucleated giant cells (Am J Surg Pathol 1988;12:484)
● Variable polygonal fragments of polyurethane
Micro images
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Vacuolated histiocytes expand Multinucleated giant cells contain
subcapsular sinus refractile material
Round silicone vacuoles of various sizes
Drawings
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Virtual Slides
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Videos
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Cytology description
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● Birefringent material with foreign body giant cells in lymphoid background (Acta Cytol 1999;43:1163)
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Sinus histiocytosis with massive lymphadenopathy
Additional references
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End of Breast-nonmalignant > Inflammatory / infectious > Silicone breast implants-axilla
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