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Breast-nonmalignant

Benign tumors / changes

Spindle cell lipoma / pleomorphic lipoma

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 8 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Lipoma with thin, uniform spindle cells associated with collagen bundles; also mature adipocytes and entrapped normal parenchyma 

 

Terminology

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● Also called benign stromal spindle cell tumor with predominant adipocytic component (AFIP fascicle, 4th series)

 

Epidemiology

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Sites

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Etiology

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● Related to myofibroblastoma (Am J Surg Pathol 2001;25:1022) and solitary fibrous tumor / hemangiopericytoma; all are benign stromal spindle cell tumors with similar immunohistochemistry, which vary based on predominant cell type present

 

Clinical features

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Prognostic factors

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Case reports

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● 28 year old woman with deep tumor of breast (Pathology 1999;31:288)

● 48 year old woman with 3 cm tumor (Indian J Pathol Microbiol 2008;51:234)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Other images: white fibrous tumor intermingling with breast tissue

 

Micro description (Histopathology)

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● Thin, uniform spindle cells associated with collagen bundles, mature adipocytes and entrapped normal parenchyma, resembling an ● infiltrating malignancy

● Nuclei are evenly spaced, regular, elongated and ovoid

● Pleomorphic lipomas have prominent floret cells

  

Micro images

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Spindle cells associated                  Cytology, H&E, CD34

with collagen and adipose

 

 

          

Spindle cells             Spindle cells are      Spindle cells are smooth

are CD34+                 desmin negative      muscle actin negative

 

Virtual Slides

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Videos

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Cytology description

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Pleomorphic lipoma - floret cells and mononuclear hyperchromatic cells with scalloped nuclei, which appear malignant (Acta Cytol 2000;44:255)

 

Cytology images

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Positive stains

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● CD34, vimentin

 

Negative stains

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● Keratin, S100, desmin, smooth muscle actin

● Factor VIII

 

Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Spindle cell lipoma / pleomorphic lipoma

 

 

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