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Breast-nonmalignant

Benign tumors / changes

Subareolar sclerosing hyperplasia of breast

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 8 October 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● A type of subareolar papillary duct hyperplasia, first described in 1987 (Cancer 1987;59:1927)

● Beneath areola, without involvement of surface of nipple (called nipple adenoma if nipple is involved)

● Note: this appears to be the only article describing this lesion 

 

Terminology

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Epidemiology

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● Mean age 46 years

 

Sites

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Etiology

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Clinical features

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Prognostic factors

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Case reports

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Treatment

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● Excisional biopsy, does not recur

 

Clinical images

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Gross description (Macroscopy)

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● Mean 1.2 cm, range 0.6 to 2.0 cm

● Variable nipple discharge

 

Gross images

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Micro description (Histopathology)

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● Central sclerosis that entraps and distorts ducts, resembling radial scar

● Small ducts with intraluminal papillary proliferation

● No squamous cysts

 

Micro images

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Complex papillary duct proliferation             Relatively solid foci in ducts surrounding

with micropapillary and microgland              sclerosis and papilloma

forming patterns

 

 

Compact papillary duct hyperplasia

with circumscribed border

 

Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Additional references

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End of Breast-nonmalignant > Benign tumors / changes > Subareolar sclerosing hyperplasia

 

 

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