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Breast-nonmalignant
Benign tumors / changes
Subareolar sclerosing hyperplasia of breast
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 5 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● A type of subareolar papillary duct hyperplasia, first described in 1987 (Cancer 1987;59:1927)
● Beneath areola, without involvement of surface of nipple (called nipple adenoma if nipple is involved)
● Note: this appears to be the only article describing this lesion
Terminology
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Epidemiology
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● Mean age 46 years
Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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● Excisional biopsy, does not recur
Clinical images
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Gross description (Macroscopy)
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● Mean 1.2 cm, range 0.6 to 2.0 cm
● Variable nipple discharge
Gross images
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Micro description (Histopathology)
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● Central sclerosis that entraps and distorts ducts, resembling radial scar
● Small ducts with intraluminal papillary proliferation
● No squamous cysts
Micro images
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Complex papillary duct proliferation Relatively solid foci in ducts surrounding
with micropapillary and microgland sclerosis and papilloma
forming patterns
Compact papillary duct hyperplasia
with circumscribed border
Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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Additional references
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End of Breast-nonmalignant > Benign tumors / changes > Subareolar sclerosing hyperplasia
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