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Breast-nonmalignant
Tubular adenosis of breast
Author: Nat Pernick, M.D. (see Authors page)
Revised: 8 October 2012, last major update - March 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Very rare benign breast lesion of haphazard, elongated tubules that are narrow and noncrowded
● May mimic invasive carcinoma or coexist with invasive or in-situ carcinoma (AJSP 1996;20:46)
Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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● Associated with adenoid cystic carcinoma but different molecular alterations (Virchows Arch 2009;454:107)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Haphazard proliferation of elongated tubules that are narrow, noncrowded, occasionally branching, not lobular
● Some tubules extend into fat; tubules contain basophilic or eosinophilic secretions and microcalcifications; tubules are lined by bland ductal cells and surrounded by myoepithelium
● May be infiltrative similar to microglandular adenosis
Micro images
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Features of collagenous spherulosis
AFIP Fig 64: mildly irregular AFIP Fig 65: tubules appear Two cell layers
tubules within stroma to branch in 3 dimensions
Drawings
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Virtual Slides
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Videos
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Cytology description
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Cytology images
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Positive stains
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● Myoepithelium: HHF35, S100
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Adenomyoepithelial adenosis: prominent myoepithelial proliferation, no tubular configuration
● Microglandular adenosis: no myoepithelial cells
● Sclerosing adenosis: lobular architecture, crowded tubules, collagenous stroma
● Tubular carcinoma: definite invasion with desmoplastic stroma and no myoepithelial cells
Additional references
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End of Breast-nonmalignant > Adenosis > Tubular adenosis
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