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Breast-nonmalignant

Tubular adenosis of breast

 

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 October 2012, last major update - March 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Very rare benign breast lesion of haphazard, elongated tubules that are narrow and noncrowded

● May mimic invasive carcinoma or coexist with invasive or in-situ carcinoma (AJSP 1996;20:46)

 

Terminology

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Epidemiology

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Sites

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Etiology

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Clinical features

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Prognostic factors

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Case reports

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● Associated with adenoid cystic carcinoma but different molecular alterations (Virchows Arch 2009;454:107)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Haphazard proliferation of elongated tubules that are narrow, noncrowded, occasionally branching, not lobular

● Some tubules extend into fat; tubules contain basophilic or eosinophilic secretions and microcalcifications; tubules are lined by bland ductal cells and surrounded by myoepithelium

● May be infiltrative similar to microglandular adenosis

 

Micro images

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Features of collagenous spherulosis

 

 

                                                                             

AFIP Fig 64: mildly irregular             AFIP Fig 65: tubules appear             Two cell layers

tubules within stroma                       to branch in 3 dimensions

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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Cytology images

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Positive stains

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Myoepithelium: HHF35, S100

 

Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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Adenomyoepithelial adenosis: prominent myoepithelial proliferation, no tubular configuration

Microglandular adenosis: no myoepithelial cells

Sclerosing adenosis: lobular architecture, crowded tubules, collagenous stroma

Tubular carcinoma: definite invasion with desmoplastic stroma and no myoepithelial cells

 

Additional references

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Stanford University

 

End of Breast-nonmalignant > Adenosis > Tubular adenosis

 

 

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