CD Markers
CD100

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update August 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD100[title]
Definition / General
  • Also called SEMA4D, semaphorin 4D
  • Integral membrane protein and ligand for CD72 and plexin-B1
  • Functions:
    1. Regulates axonal growth cone guidance in the developing CNS through its receptor plexin-B1, which may be related to its expression in invading islands of transformed epithelial cells (but not normal and noninvasive dysplastic epithelium, Proc Natl Acad Sci USA 2006;103:9017)
    2. Evokes angiogenic responses from endothelial cells (Blood 2005;105:4321)
    3. Impairs monocyte migration
    4. After vascular injury, platelet associated CD100 binds to CD100 receptors on nearby platelets to promote thrombus formation (Proc Natl Acad Sci USA 2007;104:1621)
    5. Increases CD45 induced T cell adhesion
    6. Down regulates B cell expression of CD23
  • Expression may have prognostic value in soft tissue sarcoma (Cancer 2007;110:164)
Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

Head and neck squamous cell carcinoma

Positive Staining - Normal
  • Most hematopoietic cells including platelets, increased expression after T cell activation
Negative Staining
  • Immature bone marrow cells
Additional References