CD Markers
CD100
http://www.pathologyoutlines.com/topic/cdmarkerscd100.html


Topic Completed: 1 August 2013

Revised: 3 September 2019

Revised: 14 December 2018, last major update August 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD100[title]

Nat Pernick, M.D.
Page views in 2018: 60
Page views in 2019 to date: 98
Cite this page: Pernick N. CD100. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd100.html. Accessed December 5th, 2019.
Definition / general
  • Also called SEMA4D, semaphorin 4D
  • Integral membrane protein and ligand for CD72 and plexin-B1
  • Functions:
    1. Regulates axonal growth cone guidance in the developing CNS through its receptor plexin-B1, which may be related to its expression in invading islands of transformed epithelial cells (but not normal and noninvasive dysplastic epithelium, Proc Natl Acad Sci USA 2006;103:9017)
    2. Evokes angiogenic responses from endothelial cells (Blood 2005;105:4321)
    3. Impairs monocyte migration
    4. After vascular injury, platelet associated CD100 binds to CD100 receptors on nearby platelets to promote thrombus formation (Proc Natl Acad Sci USA 2007;104:1621)
    5. Increases CD45 induced T cell adhesion
    6. Down regulates B cell expression of CD23
  • Expression may have prognostic value in soft tissue sarcoma (Cancer 2007;110:164)
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Head and neck squamous cell carcinoma

Positive staining - normal
  • Most hematopoietic cells including platelets, increased expression after T cell activation
Negative staining
  • Immature bone marrow cells
Additional references
Back to top