CD Markers
CD105

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD105 [title]
Definition / General
  • Also called endoglin
  • Regulatory component of TGF-beta receptor complex; mediates cellular response to TGF-beta 1
  • Mutations cause Hereditary Hemorrhagic Telangiectasia type I (Am J Hum Genet 1997;61:68)
  • Required for hemangioblast and early hematopoietic development (Development 2007;134:3041)
Uses by Pathologists
  • Specific and sensitive marker for tumor angiogenesis (better than CD31)
Prognostic Factors
Micro Images

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Liver, normal (fig 4)

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Hepatocellular carcinoma and normal liver

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Lung-non small cell carcinoma (fig D)

Positive Staining - Normal
  • Activated monocytes, erythroid precursors in marrow; syncytiotrophoblast, cytotrophoblast in first trimester (transient expression)
Positive Staining - Disease
Negative Staining
  • Normal endothelial cells (or weak)
Additional References