CD Markers
CD105


Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: CD105 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD105. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd105.html. Accessed November 23rd, 2020.
Definition / general
  • Also called endoglin
  • Regulatory component of TGF-beta receptor complex; mediates cellular response to TGF-beta 1
  • Mutations cause Hereditary Hemorrhagic Telangiectasia type I (Am J Hum Genet 1997;61:68)
  • Required for hemangioblast and early hematopoietic development (Development 2007;134:3041)
Uses by pathologists
  • Specific and sensitive marker for tumor angiogenesis (better than CD31)
Prognostic factors
Microscopic (histologic) images

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Hepatocellular carcinoma and normal liver

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Lung - non small cell carcinoma (fig D)

Positive staining - normal
  • Activated monocytes, erythroid precursors in marrow; syncytiotrophoblast, cytotrophoblast in first trimester (transient expression)
Positive staining - disease
Negative staining
  • Normal endothelial cells (or weak)
Additional references
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