CD Markers
CD105
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD105 [title]
CD105
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 14 May 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD105 [title]
Table of Contents
Definition / general | Uses by pathologists | Prognostic factors | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD105. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd105.html. Accessed April 18th, 2024.
Definition / general
- Also called endoglin
- Regulatory component of TGF-beta receptor complex; mediates cellular response to TGF-beta 1
- Mutations cause Hereditary Hemorrhagic Telangiectasia type I (Am J Hum Genet 1997;61:68)
- Required for hemangioblast and early hematopoietic development (Development 2007;134:3041)
Uses by pathologists
- Specific and sensitive marker for tumor angiogenesis (better than CD31)
Prognostic factors
- Increased microvessel staining:
- Acute lymphoblastic leukemia in children (Leuk Res 2007;31:1741)
- Breast carcinoma (Am J Clin Pathol 2003;119:374, including node negative, Hum Pathol 2004;35:176)
- Chronic idiopathic myelofibrosis (Mod Pathol 2004;17:1513)
- Colorectal carcinoma (Mod Pathol 2004;17:197)
- Endometrial carcinoma (Gynecol Oncol 2006;103:1007)
- Esophageal adenocarcinoma (Hum Pathol 2006;37:861)
- Gastric carcinoma (Hum Pathol 2006;37:861)
- Hepatocellular carcinoma (BMC Cancer 2006;6:110)
- Meningioma (Acta Neuropathol 2007;114:147)
- Ovarian carcinoma (Int J Gynecol Cancer 2006;16:1789)
- Primary CNS lymphoma (J Neurooncol 2007;82:249)
- Prostate adenocarcinoma (Am J Clin Pathol 2007;127:572)
- Squamous cell carcinoma of head and neck (Virchows Arch 2006;448:768), including tongue (Laryngoscope 2006;116:1175)
- Other:
- Serum endoglin is associated with intrauterine growth restriction during pregnancy (J Clin Endocrinol Metab 2007;92:2831), preeclampsia (N Engl J Med 2006;355:992, Nat Med 2006;12:642), diabetic retinopathy (J Cell Mol Med 2005;9:692)
- Tissue endoglin is associated with progressive hepatic fibrosis in chronic HCV infection (J Viral Hepat 2006;13:625) and aortic atherosclerosis (J Atheroscler Thromb 2006;13:82)
Microscopic (histologic) images
Images hosted on other servers:
Hepatocellular carcinoma and normal liver
Lung - non small cell carcinoma (fig D)
Positive staining - normal
- Activated monocytes, erythroid precursors in marrow; syncytiotrophoblast, cytotrophoblast in first trimester (transient expression)
Positive staining - disease
- Endometriosis (Reprod Biol 2005;5:51), tumor microvessels (Rom J Morphol Embryol 2007;48:41)
Negative staining
- Normal endothelial cells (or weak)
Additional references
