CD Markers

Topic Completed: 1 February 2002

Minor changes: 4 September 2019

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD105 [title]

Nat Pernick, M.D.
Page views in 2019: 372
Page views in 2020 to date: 298
Cite this page: Pernick N. CD105. website. Accessed August 7th, 2020.
Definition / general
  • Also called endoglin
  • Regulatory component of TGF-beta receptor complex; mediates cellular response to TGF-beta 1
  • Mutations cause Hereditary Hemorrhagic Telangiectasia type I (Am J Hum Genet 1997;61:68)
  • Required for hemangioblast and early hematopoietic development (Development 2007;134:3041)
Uses by pathologists
  • Specific and sensitive marker for tumor angiogenesis (better than CD31)
Prognostic factors
Microscopic (histologic) images

Images hosted on other servers:
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Liver, normal (fig 4)

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Hepatocellular carcinoma and normal liver

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Lung - non small cell carcinoma (fig D)

Positive staining - normal
  • Activated monocytes, erythroid precursors in marrow; syncytiotrophoblast, cytotrophoblast in first trimester (transient expression)
Positive staining - disease
Negative staining
  • Normal endothelial cells (or weak)
Additional references
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