CD Markers
CD109

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD109 [title]
Definition / General
  • Also called platelet activation factor
  • Glycosylphosphatidylinositol-anchored cell surface protein
  • Carries the biallelic platelet-specific Gov antigen system
    • Alloantibodies to HPA-15 residing on CD109 are implicated in refractoriness to platelet transfusion, fetal / neonatal alloimmune thrombocytopenia and posttransfusion purpura (Blood 2002;99:1692)
Positive Staining - Normal
  • Activation antigen for platelets and T cells
  • Subset of hematopoietic stem and progenitor cells (Exp Hematol 1999;27:1282)
  • Myoepithelial cells (breast, prostate [basal cells] salivary and lacrimal glands, Pathol Int 2007;57:245)
  • Widely expressed in other tissues
Negative Staining
  • Invasive ductal carcinoma (breast), prostate adenocarcinoma
Additional References