CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 September 2019

Revised: 14 December 2018, last major update February 2002

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD110 [title]

Nat Pernick, M.D.
Page views in 2019: 136
Page views in 2020 to date: 71
Cite this page: Pernick N. CD110. website. Accessed August 13th, 2020.
Definition / general
  • Also called thrombopoietin receptor (TPO-R), myeloproliferative leukemia virus oncogene (MPL)
  • Binding to thrombopoietin induces megakaryocyte proliferation and differentiation and prevents apoptosis
  • Mutations present in some patients with congenital amegakaryocytic thrombocytopenia, characterized by severe congenital thrombocytopenia with no megakaryocytes in the bone marrow (Hum Mutat 2006;27:296)
  • MPL mutations in myelofibrosis patients are associated with more severe anemia (Br J Haematol 2007;137:244)
  • Thrombopoietin receptor agonists may be useful for treating thrombocytopenia (Blood 2007;109:4739)
Uses by pathologists
  • Differentiate essential thrombocythemia (variable but weak/negative staining) from reactive thrombocytosis (positive staining, Blood 2002;99:4131)
Diagrams / tables

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Protein and site, various mutations

Positive staining - normal
  • Hematopoietic stem cells and progenitor cells (J Transl Med 2006;4:9), megakaryocytes and progenitors, platelets
Additional references
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