CD Markers
CD110

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD110 [title]
Cite this page: CD110. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd110.html. Accessed December 2nd, 2016.
Definition / General
  • Also called thrombopoietin receptor (TPO-R), myeloproliferative leukemia virus oncogene (MPL)
  • Binding to thrombopoietin induces megakaryocyte proliferation and differentiation and prevents apoptosis
  • Mutations present in some patients with congenital amegakaryocytic thrombocytopenia, characterized by severe congenital thrombocytopenia with no megakaryocytes in the bone marrow (Hum Mutat 2006;27:296)
  • MPL mutations in myelofibrosis patients are associated with more severe anemia (Br J Haematol 2007;137:244)
  • Thrombopoietin receptor agonists may be useful for treating thrombocytopenia (Blood 2007;109:4739)
Uses by Pathologists
  • Differentiate essential thrombocythemia (variable but weak/negative staining) from reactive thrombocytosis (positive staining, Blood 2002;99:4131)
Diagrams / Tables
Missing Image

Protein and site, various mutations

Positive Staining - Normal
  • Hematopoietic stem cells and progenitor cells (J Transl Med 2006;4:9), megakaryocytes and progenitors, platelets
Additional References