CD Markers
CD115

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update August 2013

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PubMed Search: CD115[title]
General
  • Aka c-fms, receptor for macrophage colony stimulating factor, CSF-1R
  • Localized on cytoplasmic membrane; mediates biologic activity of CSF-1
  • v-fms is a viral oncogene present in the feline McDonough sarcoma virus (has several substitute mutations)
  • Related to platelet derived growth factor receptor, c-kit, vascular endothelial growth factor receptor, fibroblast growth factor receptor, high affinity nerve growth factor (TrkA)
  • Deficiency causes reduced osteoclasts and macrophages, abnormal bone remodeling and osteopetrosis, abnormal breast development and decreased fertility
Positive Staining - Normal
  • Macrophages and precursors, osteoclasts, placental trophoblast, breast tissue, microglia, neurons, astrocytes
Positive Staining - Malignant
  • 10% AML, some endometrial, ovarian and breast cancers, vascular smooth muscle cells in atheromas, choriocarcinoma cells