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CD Markers

CD11a


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 21 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● An alpha integrin chain that binds to CD18 and has various leukocyte functions (see below)
● Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain

Terminology
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● Also called integrin alpha L, ITGAL, LFA-1 alpha chain (in complex with CD18)

Physiology
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● At 16p11-13.1
● An alpha integrin chain that binds to CD18 and mediates leukocyte adhesion to endothelium, leukocyte trafficking through activated endothelium, lymphocyte blastogenesis, lymphocyte-endothelial cell adhesion, lymphocyte recirculation through lymph nodes, cytotoxic T cell mediated killing and antibody dependent killing by neutrophils and monocytes
● Also mediates binding to unopsonized bacteria (e.g. E. coli) and fungi (e.g. Histoplasma capsulatum)
● With CD18, binds to ICAM1 (CD54), ICAM2 (CD102), ICAM3 (CD50) and ICAM4 (CD242)

Clinical features
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● Anti-CD11a antibody therapy (efalizumab) improves moderate/severe plaque psoriasis (J Cutan Med Surg 2003;7:198, Arch Dermatol 2002;138:591)
● Marker of differentiation in acute promyelocytic leukemia

Uses by pathologists
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● No significant clinical use by pathologists

Positive staining (normal)
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● All leukocytes

Positive staining (disease)
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● Acute promyelocytic leukemia post-treatment (treatment induces expression, Leuk Res 2008;32:315)

Negative staining
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● Platelets, various intermediate and high grade lymphomas

Additional references
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MIM 153370

End of CD Markers > CD11a


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