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CD Markers

CD11b


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 20 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Alpha component of an integrin that mediates adhesion
● Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain

Terminology
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● Also called integrin alpha M, Mac-1, CR3A

Physiology
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● At 16p11-13.1
● Mediates monocyte / macrophage / granulocyte adhesion to substrates by opsonization with iC3b, leading to phagocytosis, neutrophil aggregation, chemotaxis
● Ligands include fibrinogen, Factor X, ICAM1, iC3b, Saccharomyces cerevisiae, Staphylococcus epidermidis, Histoplasma capsulatum
● Expression is associated with activation of T cells

Clinical features
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● Gr1+ CD11b+ myeloid cells promote metastasis (Cancer Cell 2008;13:23); monoclonal antibodies to CD11b may enhance treatment response to tumor (Proc Natl Acad Sci USA 2010;107:8363)
● Poor prognostic factor in preB acute lymphoblastic leukemia (Blood 2010;115:3763)
Histoplasma capsulatum causes decreased cell surface CD11b expression and an antiapoptotic state on leukocytes (Scand J Immunol 2002;56:392)

Uses by pathologists
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● Common myeloid marker and natural killer cell antigen
● Differentiates recovery from acute agranulocytosis (CD11b+, CD117-) from acute promyelocytic leukemia (CD11b-, CD117+, Am J Clin Pathol 2002;118:31)
● Differentiates Down’s syndrome patients with AML (usually CD13+, CD11b+) from transient myeloproliferative disorder (usually CD13-, CD11b-, Am J Clin Pathol 2001;116:204)
● Documents maturation of tumor cells in acute promyelocytic leukemia patients receiving all-trans retinoic acid therapy (cells become CD11b+, CD16+, Arch Pathol Lab Med 2003;127:e4) or arsenic trioxide (CD11b+, CD33+, Mod Pathol 2000;13:954)

Positive staining (normal)
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● Granulocytes, macrophages
● Follicular dendritic cells, myeloid cells beginning with promyelocytes, NK cells, some B/T cells

Positive staining (disease)
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● Hairy cell leukemia (virtually all), acute myelogenous leukemia (Am J Clin Pathol 2008;129:934), various lymphomas, sinus histiocytosis with massive lymphadenopathy (Hum Pathol 1992;23:647)

Negative staining
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● Gaucher’s cells (Am J Clin Pathol 2004;122:359)

Micro images
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Spleen - normal

Additional references
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MIM 120980

End of CD Markers > CD11b


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