CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 December 2015, last major update September 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CD11b

Related topics: CD11, CD11a, CD11c, CD11d

Cite this page: CD11b. website. Accessed October 23rd, 2016.
Definition / General
  • Alpha component of an integrin at 16p11-13.1 that mediates adhesion (OMIM #120980)
  • Also called integrin alpha M, Mac-1 and CR3A
  • Mediates monocyte / macrophage / granulocyte adhesion to substrates by opsonization with iC3b, leading to phagocytosis, neutrophil aggregation and chemotaxis
  • Ligands include fibrinogen, Factor X, ICAM1, iC3b, Saccharomyces cerevisiae, Staphylococcus epidermidis and Histoplasma capsulatum
  • Expression is associated with activation of T cells
Clinical Features
Uses by Pathologists
  • Common myeloid marker and NK (natural killer cell) antigen
  • Differentiates recovery from acute agranulocytosis (CD11b+, CD117-) from acute promyelocytic leukemia (CD11b-, CD117+, Am J Clin Pathol 2002;118:31)
  • Differentiates Down syndrome patients with AML (usually CD13+, CD11b+) from transient myeloproliferative disorder (usually CD13-, CD11b-, Am J Clin Pathol 2001;116:204)
  • May be useful for flow cytometry diagnosis of myelodysplastic syndrome as part of panel (Ann Clin Lab Sci 2012;42:271)
Micro Images

Images hosted on other servers:

Spleen - normal

Tonsil - normal

Gastric cancer

Positive Staining - Normal
  • Granulocytes, macrophages
  • Follicular dendritic cells, myeloid cells beginning with promyelocytes, NK cells, some B/T cells
Positive Staining - Disease
Negative Staining