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CD Markers

CD11c


Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 20 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● Integrin that acts as a fibrinogen receptor, and is important in monocyte adhesion and chemotaxis
● Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain

Terminology
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● Also called integrin alpha X, CR4, LeuM5

Physiology
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● At 16p11-13.1
● Clears opsonized particles and immune complexes
● Also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium and chemotaxis

Clinical features
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● Associated with good prognosis in B-CLL

Uses by pathologists
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● Marker of histiocytes, NK cells
● Used to diagnose hairy cell leukemia (with other markers)

Positive staining (normal)
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● Granulocytes, macrophages, NK cells, dendritic cells
● 50% of activated CD4/CD8+ T cells

Positive staining (disease)
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● Hairy cell leukemia (classic and variant, virtually all cases, (Am J Clin Pathol 1991;96:100)
● AML-M4 and M5 (50%), follicular lymphoma (some), Langerhans cell histiocytosis, lymphoplasmacytic lymphoma (81%, Am J Clin Pathol 2005;124:414), psoriatic skin lesions (Proc Natl Acad Sci USA 2005;102:19057), sinus histiocytosis with massive lymphadenopathy (Hum Pathol 1992;23:647), small lymphocytic lymphoma (Am J Clin Pathol 1998;110:582), splenic lymphoma with villous lymphocytes (Am J Clin Pathol 1988;90:250)

Negative staining
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● Mantle cell lymphoma (Am J Clin Pathol 2010;134:271), AML-M3 (Am J Clin Pathol 1998;109:211), splenic and non-splenic marginal zone lymphoma (Am J Clin Pathol 1996;105:277)

Micro images
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Normal appendix

Hairy cell leukemia - contributed by Leica Microsystems

Hairy cell leukemia

Additional references
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MIM 151510

End of CD Markers > CD11c


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