CD Markers
CD11c


Topic Completed: 2 September 2013

Revised: 9 November 2019

Copyright: 2012-2019, PathologyOutlines.com, Inc.

PubMed Search: CD11c

Related topics: CD11, CD11a, CD11b, CD11d

Nat Pernick, M.D.
Page views in 2018: 1,421
Page views in 2019 to date: 1,999
Cite this page: Pernick, N. CD11c. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd11c.html. Accessed November 21st, 2019.
Definition / general
  • Integrin at 16p11-13.1 that acts as a fibrinogen receptor, and is important in monocyte adhesion and chemotaxis (OMIM #151510)
  • Also called integrin alpha X, CR4 and LeuM5
Pathophysiology
  • Clears opsonized particles and immune complexes
  • Also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium and chemotaxis
  • CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity (Diabetes 2010;59:1648)
Clinical features
Uses by pathologists
  • Marker of histiocytes, NK cells
  • Used to diagnose hairy cell leukemia (with other markers)
Microscopic (histologic) images

Images hosted on PathOut server:
Missing Image

Hairy cell leukemia
(by Leica Microsystems)

Positive staining - normal
  • Granulocytes, macrophages, NK cells, dendritic cells (PLoS One 2012;7:e33556)
  • 50% of activated CD4 / CD8+ T cells
Positive staining - disease
Negative staining
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