CD Markers
CD11c

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 July 2018, last major update September 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CD11c

Related topics: CD11, CD11a, CD11b, CD11d

Cite this page: Pernick, N. CD11c. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd11c.html. Accessed November 20th, 2018.
Definition / general
  • Integrin at 16p11-13.1 that acts as a fibrinogen receptor, and is important in monocyte adhesion and chemotaxis (OMIM #151510)
  • Also called integrin alpha X, CR4 and LeuM5
Pathophysiology
  • Clears opsonized particles and immune complexes
  • Also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium and chemotaxis
  • CD11c+ CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity (Diabetes 2010;59:1648)
Clinical features
Uses by pathologists
  • Marker of histiocytes, NK cells
  • Used to diagnose hairy cell leukemia (with other markers)
Microscopic (histologic) images

Images hosted on PathOut server:

Hairy cell leukemia
(by Leica Microsystems)

Positive staining - normal
  • Granulocytes, macrophages, NK cells, dendritic cells (PLoS One 2012;7:e33556)
  • 50% of activated CD4 / CD8+ T cells
Positive staining - disease
Negative staining