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CD Markers
CD11d
Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 14 December 2010, last major update December 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
General
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● Receptor for ICAM3 (CD50) and VCAM1 (CD106) at 16p11.2
Terminology
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● Also called integrin alpha D
Physiology
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● May play a role in the atherosclerotic process, such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter and senescent erythrocytes from the blood
● Monoclonal anti-CD11d antibody may have a neuroprotective effect in spinal cord injury (J Neuroimmunol 2004;156:42)
● May play a role in monocyte/macrophage migration (Exp Cell Res 2008;314:2569)
Uses by pathologists
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● No significant clinical use by pathologists
Cytology images
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Hemophagocytic histiocytes in bone marrow are CD11d+
Positive staining (normal)
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● Myeloid and monocytic cells; splenic red pulp macrophages, peripheral blood leukocytes (some)
Positive staining (nontumor)
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● Macrophage foam cells within atherosclerotic plaques
Negative staining
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● B cells, follicular dendritic cells
Additional references
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End of CD Markers > CD11d
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