CD Markers
CD13

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update September 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD13[title], Aminopeptidase N[title]
Definition / General
  • Myeloid antigen, although CD33 is more specific (OMIM #151530)
  • Also called aminopeptidase N (APN)
Clinical Features
Pathophysiology
  • Cleaves peptides at brush border of small intestine, renal proximal tubules and placenta
  • Cleaves antigen peptides bound to MHC class II molecules of presenting cells
  • Degrades neurotransmitters at CNS synaptic junctions
  • Regulates sperm motility (Asian J Androl 2010;12:899)
Uses by Pathologists
Micro Images

Images hosted on Pathout server:

Prostate: normal
(contributed by Leica Microsystems)



Images hosted on other servers:

CNS: glioblastoma & colon: carcinoma

Colon: normal

Liver: left-normal, right-hepatocellular carcinoma


Prostate: carcinoma

Skin (inflammatory), tonsil

Various tumors

Positive Staining - Normal
  • Granulocytes (most, but low levels in newbornss, Mod Pathol 1993;6:414), interdigitating dendritic cells, large granular lymphocytes (some), macrophages, mast cells, monocytes, myelomonocytes and osteoclasts
  • Also bile duct canaliculi, central nervous system synapses, endothelial cells, endometrial stromal cells, fibroblasts, liver, perineurium of peripheral nerves, placenta, prostate secretory cells, renal proximal tubules (PLoS One 2013;8:e66750), respitatory epithelium, small intestine and sperm
Positive Staining - Disease
Negative Staining
Flow Cytometry Images

CD13+ anaplastic large cell lymphoma