CD Markers

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 3 October 2018, last major update June 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD133[title]
Cite this page: Pernick, N. CD133. website. Accessed October 19th, 2018.
Definition / general
  • Also known as Prominin 1, AC133
  • Transmembrane glycoprotein expressed on the hematopoietic stem cells, endothelial progenitors, and dermal-derived stem cells capable of differentiating into neural cells
Uses by pathologists
  • Alternative to CD34 in selecting hematopoietic stem and progenitor cells for transplantation studies
  • Marker of cancer stem cells (cells with tumor initiating potential, Genes Chromosomes Cancer 2012;51:792
Clinical features
Microscopic (histologic) images

Images hosted on other servers:

Glial tumors

Hepatocellular carcinoma
and intrahepatic
(Figure 3)

Pancreas - normal

Stomach - gastric carcinoma

Colorectal carcinoma

Positive staining - normal
  • Localized to microvilli and other plasma membrane protrusions
  • CD34 bright hematopoietic stem and progenitor cells (umbilical cord blood-derived CD133+ cells can differentiate into endothelial cells and induce new blood vessel growth, Front Biosci 2012;17:2247)
  • Progenitor cells within nephron (Expert Opin Ther Targets 2012;16:157)
  • Neural stem cells and other primitive cells such as retina
  • Villous and extravillous cytotrophoblast, syncytiotrophoblast
Positive staining - disease
  • Numerous malignancies
  • Brain tumors (CD133+ cells have characteristics of endothelial progenitor cells, Cancer Lett 2012;324:221)
Negative staining
  • Adult epithelial tissue, villous stroma