CD Markers
CD138

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 31 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD138[title]
Definition / General
  • Aka heparan sulfate proteoglycan, syndecan-1
  • Mediates cell adhesion, growth factors; associated with late stage of B cell differentiation
  • Integral membrane protein is a receptor for extracellular matrix
  • Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC-in situ
Interpretation
  • Membranous staining
Micro Images

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Keratoacanthoma

Invasive squamous cell carcinoma

Positive Staining - Normal
  • B cell precursors, plasma cells, stratified squamous epithelium
Positive staining - Tumors
  • Keratoacanthoma, myeloma, plasmablastic lymphoma (strong), primary effusion lymphoma, pyothorax associated lymphoma
Negative Staining
  • Mature B cells, other lymphomas (even plasmacytoid lymphomas)