CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 May 2018, last major update February 2002

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD138[title]
Cite this page: Pernick, N. CD138. website. Accessed December 15th, 2018.
Definition / general
  • Aka heparan sulfate proteoglycan, syndecan-1
  • Mediates cell adhesion, growth factors; associated with late stage of B cell differentiation
  • Integral membrane protein is a receptor for extracellular matrix
  • Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC in situ
  • Membranous staining
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Yuri Tachibana, M.D., Nagasaki University:

Chronic endometritis

Positive staining - normal
  • B cell precursors, plasma cells, stratified squamous epithelium
Positive staining - tumors
  • Keratoacanthoma, myeloma, plasmablastic lymphoma (strong), primary effusion lymphoma, pyothorax associated lymphoma
Negative staining
  • Mature B cells, other lymphomas (even plasmacytoid lymphomas)