CD Markers
CD142

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 January 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: CD142[title]
Definition / General
  • Aka coagulation Factor III, thromboplastin, tissue factor
  • Major initiator of clotting in normal hemostasis and many thrombotic diseases, via complex with factor VIIa
  • Also binds zymogen factor VII, the inactive precursor form; once bound, a variety of serine proteases rapidly activate factor VII to VIIa via limited proteolysis
  • Normally absent from all cells in direct contact with plasma
Positive Staining - Normal
  • Epidermal keratinocytes, glomerular epithelial cells and various other epithelia, adventitial cells of blood vessels, astrocytes, myocardium, Schwann cells, stromal cells of liver, pancreas, spleen and thyroid