CD Markers

Topic Completed: 1 August 2013

Revised: 17 December 2018, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: CD142[title]

Nat Pernick, M.D.
Page views in 2019: 41
Page views in 2020 to date: 18
Cite this page: Pernick N. CD142. website. Accessed August 13th, 2020.
Definition / general
  • Aka coagulation Factor III, thromboplastin, tissue factor
  • Major initiator of clotting in normal hemostasis and many thrombotic diseases, via complex with factor VIIa
  • Also binds zymogen factor VII, the inactive precursor form; once bound, a variety of serine proteases rapidly activate factor VII to VIIa via limited proteolysis
  • Normally absent from all cells in direct contact with plasma
Positive staining - normal
  • Epidermal keratinocytes, glomerular epithelial cells and various other epithelia, adventitial cells of blood vessels, astrocytes, myocardium, Schwann cells, stromal cells of liver, pancreas, spleen and thyroid
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