CD Markers

Topic Completed: 1 August 2013

Revised: 18 December 2018, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: CD143[title]

Nat Pernick, M.D.
Page views in 2018: 76
Page views in 2019 to date: 126
Cite this page: Pernick N. CD143. website. Accessed October 21st, 2019.
Definition / general
  • Aka angiotensin-converting enzyme, ACE, peptidyl dipeptidase A
  • Involved in metabolism of angiotensin II and bradykinin; also cleaves substance P and LH-RH
  • Patients with high activity have DD genotype, associated with MI, strokes, diabetic nephropathy
  • Necessary for spermatozoa to bind to egg and associated with better penetration of egg
Positive staining - normal
  • Endothelial cells of small/medium arteries, lung capillary endothelium, proximal renal tubule brush borders, basal ganglia neuropil, granulosa cells, Leydig cells, variable on other cells
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