CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 January 2016, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: CD143[title]
Cite this page: CD143. website. Accessed October 20th, 2018.
Definition / general
  • Aka angiotensin-converting enzyme, ACE, peptidyl dipeptidase A
  • Involved in metabolism of angiotensin II and bradykinin; also cleaves substance P and LH-RH
  • Patients with high activity have DD genotype, associated with MI, strokes, diabetic nephropathy
  • Necessary for spermatozoa to bind to egg and associated with better penetration of egg
Positive staining - normal
  • Endothelial cells of small/medium arteries, lung capillary endothelium, proximal renal tubule brush borders, basal ganglia neuropil, granulosa cells, Leydig cells, variable on other cells