CD Markers
CD143

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 January 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: CD143[title]
Cite this page: CD143. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd143.html. Accessed December 2nd, 2016.
Definition / General
  • Aka angiotensin-converting enzyme, ACE, peptidyl dipeptidase A
  • Involved in metabolism of angiotensin II and bradykinin; also cleaves substance P and LH-RH
  • Patients with high activity have DD genotype, associated with MI, strokes, diabetic nephropathy
  • Necessary for spermatozoa to bind to egg and associated with better penetration of egg
Positive Staining - Normal
  • Endothelial cells of small/medium arteries, lung capillary endothelium, proximal renal tubule brush borders, basal ganglia neuropil, granulosa cells, Leydig cells, variable on other cells