CD Markers
CD15

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 July 2018, last major update January 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CD15[title]

Related topics: CD15s, CD15u

Cite this page: Pernick, N. CD15. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd15.html. Accessed August 19th, 2018.
Definition / general
  • A carbohydrate (not a protein) widely used for diagnosis of Hodgkin lymphoma
  • Also known as LeuM1, Lewis X, 3-fucosyl-N-acetyl-lactosamine
  • Mediates phagocytosis and chemotaxis
  • Synthesis is directed by FUT4 (OMIM #104230) in lymphoid cells and mature granulocytes, and by FUT9 (OMIM #606865) in promyelocytes and monocytes
  • References: Quality control for CD15
Clinical features
Uses by pathologists
  • Hodgkin lymphoma: membranous, diffuse cytoplasmic or Golgi staining of Reed-Sternberg cells; CD15 staining is used to confirm diagnosis, or to differentiate Hodgkin lymphoma (CD15+) from anaplastic large cell lymphoma (usually CD15-)
  • Granulocyte marker
Case reports
Microscopic (histologic) images

Images hosted on PathOut server:

Lymph node - Hodgkin
lymphoma: membranous,
cytoplasmic and
golgi staining

Hodgkin lymphoma - nodular
lymphocyte predominant:
LP cells are CD15- but
classic RS cells are CD15+

Renal cell carcinoma: papillary type



Images hosted on other servers:

Small intestine: normal Paneth cells (fig B)

Hodgkin lymphoma: comparison of antibodies

Colon: invasive colorectal carcinoma

Positive staining - normal
  • Myeloid cells and eosinophils; activated B and T cells (including infectious mononucleosis); variable monocytes and basophils
  • Kidney proximal convoluted tubules; small intestine Paneth cells (J Clin Pathol 1996;49:474)
Positive staining - disease
Negative staining