Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 28 August 2013, last major update February 2002
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD154[title]
- Aka CD40 ligand, CD40L, TNF-related activation protein (TRAP)
- Regulates B cell function by engaging CD40
- Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS-positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma, and adenocarcinoma) and Cryptosporidium parvum infection
Positive staining (normal)
End of CD Markers > CD154
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