CD Markers

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update February 2002

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD154[title]
Cite this page: CD154. website. Accessed October 26th, 2016.
Definition / General
  • Aka CD40 ligand, CD40L, TNF-related activation protein (TRAP)
  • Regulates B cell function by engaging CD40
  • Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS-positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma, and adenocarcinoma) and Cryptosporidium parvum infection
Positive Staining - Normal
  • T cells