Cite this page: Pernick N. CD158. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd158.html. Accessed January 22nd, 2019.
Definition / general
- Member of KIR (killer cell immunoglobulin like receptor) family, also called killer cell inhibitory receptors
- Binding by HLA class I molecules causes inhibition of NK or T cell cytotoxic activity
- Melanoma specific cytotoxic T lymphocytes may express KIR and regulate their ability to kill these tumors
Positive staining - normal
- Natural killer cells (NK cells), some T cells