CD Markers
CD158


Topic Completed: 1 February 2002

Revised: 31 October 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: CD158


Nat Pernick, M.D.
Page views in 2018: 152
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Cite this page: Pernick N. CD158. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd158.html. Accessed December 14th, 2019.
Definition / general
  • Member of KIR (killer cell immunoglobulin like receptor) family, also called killer cell inhibitory receptors
  • Binding by HLA class I molecules causes inhibition of NK or T cell cytotoxic activity
  • Melanoma specific cytotoxic T lymphocytes may express KIR and regulate their ability to kill these tumors
Terminology
  • CD158c - KIR2DS6 / KIRX
  • CD158d - KIR2DL4
  • CD158e1 - KIR3DL1 / p70
  • CD158e2 - KIR3DS1 / p70
  • CD158f - KIR2DL5
  • CD158g - KIR2DS5
  • CD158h - KIR2DS1 / p50.1
  • CD158i - KIR2DS4 / p50.3
  • CD158j - KIR2DS2 / p50.2
  • CD158k - KIR3DL2 / p140
  • CD158z - KIR3DL7 / KIRC1
Positive staining - normal
  • Natural killer cells (NK cells), some T cells
CD158A
  • Aka KIR2DL1 / p58.1
  • Regulates NK cell mediated cytolytic activity
  • Includes two different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
  • Positive staining: NK cell subset
    CD158b
    • CD158b1 aka KIR2DL2 / p58.2
    • CD158b2 aka KIR2DL3 / p58.3
    • Regulates NK cell mediated cytolytic activity
    • Includes two different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
    • Positive staining: NK cell subset, rare T cells
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