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CD Markers

CD15s


Reviewers: Nat Pernick, M.D., PathologyOutlines.com (see Reviewers page)
Revised: 6 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Biochemically similar to CD15, but with different functions

Terminology
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● Also known as sialyl Lewis X

Physiology
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● Differs from CD15 by addition of a sialic acid; myeloid maturation is accompanied by relative loss of CD15s and gain of CD15 expression (Nat Chem Biol 2008;4:751)
● Mediates leukocyte rolling (Proc Natl Acad Sci USA 1997;94:3172)
● Ligand (receptor) for CD62P and CD62E
● May play a role in cluster formation in lymphoid follicles (Immunol Lett 2001;79:181)

Clinical features
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● Deficiency causes Rambam-Hasharon syndrome (MIM 266265), also called leukocyte adhesion deficiency 2 (eMedicine)
● Expression is correlated with susceptibility to human granulocytic ehrlichiosis (J Clin Invest 1999;103:407)
● Exhibits reversed cell polarity in invasive micropapillary carcinoma of breast (Int J Surg Pathol 2010;18:193)

Uses for pathologists
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● No significant clinical use by pathologists

Micro images
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Fluorescence associated with susceptibility to human granulocytic ehrlichiosis

Positive stains - normal
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● Granulocytes, macrophages; also some T cells, B cells, NK cells

Positive stains - disease
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● Cirrhosis, metastatic carcinoma, fibrolamellar and other hepatocellular carcinoma (Arch Pathol Lab Med 1992;116:643)
● CD4+ CD56+ neoplasia (Leuk Lymphoma 2003;44:281), Sezary syndrome (J Am Acad Dermatol 2001;44:456)

Negative stains
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● Normal hepatocytes

End of CD Markers > CD15s


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