CD Markers
CD15u

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update January 2014

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: sialyl 6-sulfo Lewis

Related topics: CD15, CD15s

Definition / General
  • Adhesion protein representing the sulfated form of CD15
  • Also called sialyl 6-sulfo Lewis
  • Major L-selectin ligand on high endothelial venules of human peripheral lymph nodes (Biochem Biophys Res Commun 2000;278:90)
Diagrams / Tables

Sulfating L-selectin ligands

Uses by Pathologists
  • No significant clinical use by pathologists
Micro Images

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Colorectal cancer

Skin

Positive Staining - Normal
  • Neutrophils, basophils, mature granulocytes, monocytes, NK cells and T lymphocytes
  • Also immature bone marrow cells, endothelial cells of high endothelium (HEV) of peripheral lymph nodes
  • Expression on lymphocytes is variable depending on the antibodies used for detection
Positive Staining - Disease
  • Myelomonocytic leukemia cells, adenocarcinoma