CD Markers
CD167a

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 January 2016, last major update February 2002

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD167
Cite this page: CD167a. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd167.html. Accessed December 10th, 2016.
Definition / General
  • A.K.A. Discoidin Domain Receptor 1 (DDR1)
  • Has homologous region to the Dicytostelium discoideum protein discoidin I in extracellular domain
  • Tyrosine kinase receptor, may be important in cytoskeletal organization and the ability to align with other cells during aggregation
  • Receptor tyrosine kinases help cells communicate with their microenvironment and regulate cell growth, differentiation and metabolism
  • Activated by collagen types I - V, VIII
  • May have a role in tumor invasion and metastasis
Positive Staining - Normal
  • Epithelial cells (breast, kidney, lung, GI, brain)
Positive Staining - Disease
  • Carcinomas (various)