CD Markers
CD16b

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update December 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CD16b[title]

Related topics: CD16a

General
  • The most common receptor for the Fc domain of IgG on leukocytes
  • Also known as Fc gamma receptor III B, low affinity immunoglobulin gamma Fc region receptor III-B
  • Has allotypes that define the human neutrophil antigen-1 (HNA-1 and NA) system involved in major post-transfusional reactions (Tissue Antigens 2004;64:119)
  • Polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis (Lung 2010;188:475)
  • Polymorphisms may be associated with malaria (PLoS One 2012;7:e46197, Hum Genet 2012;131:289)
  • Low copy number is associated with glomerulonephritis in systemic lupus erythematosus (Nature 2006;439:851)
  • CD16+ eosinophils are upregulated in allergic conditions (J Allergy Clin Immunol 2002;109:463)
Pathophysiology
  • Highly homologous to CD16a
  • The only Fc receptor linked to the plasma membrane by a GPI (glycosylphosphatidylinositol) anchor
  • Occurs in two codominantly expressed allelic variants, NA1 and NA2, which exhibit different binding affinities for IgG1 and IgG3 subclasses
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal