CD Markers - CD16b

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CD Markers

CD16b

Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 22 December 2010, last major update November 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● The most common receptor for the Fc domain of IgG on leukocytes

Terminology
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● Also known as Fc gamma receptor III B, low affinity immunoglobulin gamma Fc region receptor III-B

Physiology
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● Highly homologous to CD16a
● The most common receptor for the Fc domain of IgG on leukocytes
● The only Fc receptor linked to the plasma membrane by a GPI (glycosylphosphatidylinositol) anchor
● Occurs in two codominantly expressed allelic variants, NA1 and NA2, which exhibit different binding affinities for IgG1 and IgG3 subclasses

Clinical features
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● Bears allotypes that define the human neutrophil antigen-1 (HNA-1 and NA) system involved in major post-transfusional reactions (Tissue Antigens 2004;64:119)
● Low copy number is associated with glomerulonephritis in systemic lupus erythematosus (Nature 2006;439:851)
● CD16+ eosinophils are upregulated in allergic conditions (J Allergy Clin Immunol 2002;109:463)

Uses by pathologists
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● No significant clinical use by pathologists

Positive staining (normal)
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● Neutrophils, basophils (J Immunol 2009;182:2542)

End of CD Markers > CD16b

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